Multiple growth factors and extracellular signals can lead to activation of the c-Jun amino N-
terminal protein kinase (JNK) pathway. Activation of JNK can in turn lead to a multitude of …

We describe a computational approach that integrates GRO-seq and RNA-seq data to
annotate long noncoding RNAs (lncRNAs), with increased sensitivity for low-abundance …

Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that are essential
nodes in many cellular regulatory circuits including those that take place on DNA. Most …

Endometrioid endometrial carcinoma (EEC) is one of the common causes of cancer-related
mortality in women. Mounting evidences suggest that long noncoding RNAs (lncRNAs) …

A critical mechanism that has been proposed for transcription regulation by estrogen
receptor α (ER) is the tethering of ER to DNA via other transcription factors, such as AP-1 …

Endometrial cancer is one of the most common gynecological malignant tumors. The roles of
competing endogenous RNAs (ceRNAs) in this disease, however, remain unclear. In this …

The c-Jun N-terminal kinases (JNK) play an important role in many physiologic processes
induced by numerous stress signals. Each JNK protein appears to have a distinct function in …

Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor
alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex …

Estrogen receptor-positive breast cancer (ERPBC) is the commonest subtype of breast
cancer, with a high prevalence, incidence, and mortality. Herbal drugs are increasingly …

X-linked inhibitor of apoptosis-associated factor 1 (XAF1) is a pro-apoptotic tumor
suppressor that is frequently inactivated in multiple human cancers. However, its candidacy …