RNA-binding proteins in human genetic disease

F Gebauer, T Schwarzl, J Valcárcel… - Nature Reviews …, 2021 - nature.com
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …

An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity

E Masini, E Loi, AF Vega-Benedetti, M Carta… - International journal of …, 2020 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects social
interaction and communication, with restricted interests, activity and behaviors. ASD is highly …

Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury

ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …

A Parkinson's disease Circ RNA s resource reveals a link between circ SLC 8A1 and oxidative stress

M Hanan, A Simchovitz, N Yayon… - EMBO molecular …, 2020 - embopress.org
Circular RNA s (circ RNA s) are brain‐abundant RNA s of mostly unknown functions. To
seek their roles in Parkinson's disease (PD), we generated an RNA sequencing resource of …

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

B Tsang, J Arsenault, RM Vernon… - Proceedings of the …, 2019 - National Acad Sciences
Activity-dependent translation requires the transport of mRNAs within membraneless protein
assemblies known as neuronal granules from the cell body toward synaptic regions …

MicroRNA as biomarkers and diagnostics

J Wang, J Chen, S Sen - Journal of cellular physiology, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small non‐coding RNAs that are involved in regulating
a range of developmental and physiological processes; their dysregulation has been …

A synaptic perspective of fragile X syndrome and autism spectrum disorders

C Bagni, RS Zukin - Neuron, 2019 - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease

H Walgrave, S Balusu, S Snoeck, EV Eynden… - Cell Stem Cell, 2021 - cell.com
Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …

Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity

B Xu, Y Zhang, XF Du, J Li, HX Zi, JW Bu, Y Yan, H Han… - Cell research, 2017 - nature.com
Vascular integrity helps maintain brain microenvironment homeostasis, which is critical for
the normal development and function of the central nervous system. It is known that neural …

The widespread regulation of microRNA biogenesis, function and decay

J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …