RNA-binding proteins in human genetic disease
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity
E Masini, E Loi, AF Vega-Benedetti, M Carta… - International journal of …, 2020 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects social
interaction and communication, with restricted interests, activity and behaviors. ASD is highly …
interaction and communication, with restricted interests, activity and behaviors. ASD is highly …
Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury
ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …
their families, but currently no drugs on the market promote neurological recovery. Limited …
A Parkinson's disease Circ RNA s resource reveals a link between circ SLC 8A1 and oxidative stress
M Hanan, A Simchovitz, N Yayon… - EMBO molecular …, 2020 - embopress.org
Circular RNA s (circ RNA s) are brain‐abundant RNA s of mostly unknown functions. To
seek their roles in Parkinson's disease (PD), we generated an RNA sequencing resource of …
seek their roles in Parkinson's disease (PD), we generated an RNA sequencing resource of …
Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation
B Tsang, J Arsenault, RM Vernon… - Proceedings of the …, 2019 - National Acad Sciences
Activity-dependent translation requires the transport of mRNAs within membraneless protein
assemblies known as neuronal granules from the cell body toward synaptic regions …
assemblies known as neuronal granules from the cell body toward synaptic regions …
MicroRNA as biomarkers and diagnostics
J Wang, J Chen, S Sen - Journal of cellular physiology, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small non‐coding RNAs that are involved in regulating
a range of developmental and physiological processes; their dysregulation has been …
a range of developmental and physiological processes; their dysregulation has been …
A synaptic perspective of fragile X syndrome and autism spectrum disorders
C Bagni, RS Zukin - Neuron, 2019 - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease
H Walgrave, S Balusu, S Snoeck, EV Eynden… - Cell Stem Cell, 2021 - cell.com
Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …
Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity
Vascular integrity helps maintain brain microenvironment homeostasis, which is critical for
the normal development and function of the central nervous system. It is known that neural …
the normal development and function of the central nervous system. It is known that neural …
The widespread regulation of microRNA biogenesis, function and decay
J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …
that are∼ 21 nucleotides in length and control many developmental and cellular processes …