Diet is a critical element determining human health and diseases, and unbalanced food
habits are major risk factors for the development of obesity and related metabolic disorders …

Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein most
abundantly found in the outer membrane of neurons. Due to structural characteristics (a …

Background: The triglyceride glucose index (TyG index) has been proposed as a simple and
credible surrogate marker of insulin resistance. However, it is unclear whether TyG index …

Insulin resistance often refers to a pathological condition in which cells fail to respond to the
normal actions of insulin. Increasing literature has noted a critical role of insulin resistance in …

Amyloid cross-seeding, as a result of direct interaction and co-aggregation between different
disease-causative peptides, is considered as a main mechanism for the spread of the …

Although cellular prion protein (PrP c) has been suggested to have physiological roles in
neurogenesis and angiogenesis, the pathophysiological relevance of both processes …

The prion protein (PrPC), a mainly neuronal protein, is known to modulate glucose
homeostasis in mouse models. We explored the underlying mechanism in mouse models …

Neurodegenerative diseases such as stroke and Alzheimer's disease (AD) are two inter-
related disorders that affect the neurons in the brain and central nervous system. Alzheimer's …

Sport-related mild traumatic brain injury (mTBI) or concussion is a significant health concern
to athletes with potential long-term consequences. The diagnosis of sport concussion and …

Cellular (also termed 'natural') prion protein has been extensively studied for many years for
its pathogenic role in prionopathies after misfolding. However, neuroprotective properties of …