Endosomes serve as signaling platforms for RIG-I ubiquitination and activation
KR Chen, CY Yang, SG Shu, YC Lo, KW Lee… - Science …, 2024 - science.org
RIG-I–like receptors (RLRs) are cytosolic RNA sensors critical for antiviral immunity. RLR
activation is regulated by polyubiquitination and oligomerization following RNA binding. Yet …
activation is regulated by polyubiquitination and oligomerization following RNA binding. Yet …
Notch signaling in prevention and therapy: fighting cancer with a two-sided sword
J Reichrath, S Reichrath - Notch Signaling in Embryology and Cancer …, 2021 - Springer
The evolutionary conserved Notch pathway that first developed in metazoans and that was
first discovered in fruit flies (Drosophila melanogaster) governs fundamental cell fate …
first discovered in fruit flies (Drosophila melanogaster) governs fundamental cell fate …
Using Drosophila melanogaster to Analyse the Human Paralogs of the ESCRT-III Core Component Shrub/CHMP4/Snf7 and Its Interactions with Members of the LGD …
M Baeumers, K Schulz, T Klein - International Journal of Molecular …, 2022 - mdpi.com
The evolutionary conserved ESCRT-III complex is a device for membrane remodelling in
various cellular processes, such as the formation of intraluminal vesicles (ILVs), cytokinesis …
various cellular processes, such as the formation of intraluminal vesicles (ILVs), cytokinesis …
The molecular role of HIF1α is elucidated in chronic myeloid leukemia
Chronic myeloid leukemia (CML) is potentially fatal blood cancer, but there is an unmet
need to discover novel molecular biomarkers. The hypothesis of this study aimed to …
need to discover novel molecular biomarkers. The hypothesis of this study aimed to …
Lgd regulates ESCRT-III complex accumulation at multivesicular endosomes to control intralumenal vesicle formation
AL Clarke, MM Lettman, A Audhya - Molecular Biology of the Cell, 2022 - Am Soc Cell Biol
Membrane remodeling mediated by heteropolymeric filaments composed of ESCRT-III
subunits is an essential process that occurs at a variety of organelles to maintain cellular …
subunits is an essential process that occurs at a variety of organelles to maintain cellular …
[HTML][HTML] Myelin and lymphocyte protein 2 regulates cell proliferation and metastasis through the Notch pathway in prostate adenocarcinoma
C Zheng, J Wang, J Zhang, S Hou… - Translational …, 2021 - ncbi.nlm.nih.gov
Background Myelin and lymphocyte protein 2 (MAL2) is a proven oncogene in some human
tumors. However, currently, little is known about the function of MAL2 in prostate …
tumors. However, currently, little is known about the function of MAL2 in prostate …
In-vitro study of cytotoxic and apoptotic potential of Thalassia hemprichii (Ehren.) Asch. And Enhalus acoroides (Lf) Royle against human breast cancer cell line …
SIA Mohamed, GH Elsayed, A El Shaffai… - … Medicine and Therapies, 2024 - Springer
Background Breast cancer is the most common type of cancer diagnosed in women. Finding
novel therapeutic agents with significant cytotoxic action and minimal adverse impact on …
novel therapeutic agents with significant cytotoxic action and minimal adverse impact on …
[HTML][HTML] Structural Analysis of the ESCRT-III Regulator Lethal (2) Giant Discs/Coiled-Coil and C2 Domain-Containing Protein 1 (Lgd/CC2D1)
T Breuer, C Tibbe, T Troost, T Klein - Cells, 2024 - mdpi.com
Members of the LGD/CC2D1 protein family contain repeats of the family-defining DM14
domains. Via this domain, they interact with members of the CHMP family, which are …
domains. Via this domain, they interact with members of the CHMP family, which are …
Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery
M Baeumers, K Ruhnau, T Breuer, H Pannen… - BMC biology, 2020 - Springer
Background A major task of the endosomal sorting complex required for transport (ESCRT)
machinery is the pinching off of cargo-loaded intraluminal vesicles (ILVs) into the lumen of …
machinery is the pinching off of cargo-loaded intraluminal vesicles (ILVs) into the lumen of …
[图书][B] LGD-1 Regulation of ESCRT-III during Multivesicular Endosome Biogenesis
AL Clarke - 2022 - search.proquest.com
Abstract The Endosomal Sorting Complexes Required for Transport (ESCRT) machinery
facilitates several membrane remodeling events that occur throughout a cell which are …
facilitates several membrane remodeling events that occur throughout a cell which are …