Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential
process for mammalian cell survival. An enzyme responsible for this process, sodium …

Abstract Na+/K+-ATPase (NKA) is a plasma membrane ion-transporting protein involved in
the generation and maintenance of Na+ and K+ gradients across the cell membrane, which …

(+)-Digoxin (1) is a well-known cardiac glycoside long used to treat congestive heart failure
and found more recently to show anticancer activity. Several known cardenolides (2–5) and …

Abstract Digitalis L.(Foxglove, Plantaginaceae) genus is a representative of several
medicinal ornamental plants that are widely used in the production of herbal medicines …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide. Although many therapeutic options are available, several factors, including the …

Cardiovascular and cancer diseases are the first causes of death in the world. Digitalis
purpurea L. is a medicinal plant that produces secondary metabolites, like digoxin and …

Digoxin is a cardiac glycoside long used to treat congestive heart failure and found recently
to show antitumor potential. The hydroxy groups connected at the C-12, C-14, and C-3′ a …

Bufadienolide compounds have been used for growth inhibition and apoptosis induction in
tumor cells. Those families of cardiotonic steroids can bind the Na, K-ATPase, causing its …

P‑class pumps are specific ion transporters involved in maintaining intracellular/extracellular
ion homeostasis, gene transcription, and cell proliferation and migration in all eukaryotic …

Cardiotonic steroids (CTS) are steroidal drugs, processed from the seeds and dried leaves
of the genus Digitalis as well as from the skin and parotid gland of amphibians. The most …