Inflammation is central to pathogenic processes in diabetes mellitus and the metabolic
syndrome and particularly implicates innate immunity in the development of complications …

Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Adipose tissue regulates metabolic homeostasis by participating in endocrine and immune
responses in addition to storing and releasing lipids from adipocytes. Obesity skews adipose …

Flavones are natural phytochemicals broadly distributed in our diet. Their anti-inflammatory
properties provide unique opportunities to control the innate immune system and …

Monocytes play a key role in the development of metabolic syndrome, and especially
obesity. Given the complex features of their development from progenitor cells, whose …

The 'apple-shaped'anatomical pattern that accompanies visceral adiposity increases risk for
multiple chronic diseases, including conditions that impact the brain, such as diabetes and …

Obesity has been linked to an increased risk of and a worse prognosis for several types of
cancer. A number of interrelated mediators contribute to obesity's pro-tumor effects …

Bacteria and mammals exhibit all aspects of symbiosis. Metabolic flux in bacteria and in
specific host cells can influence host-microbe symbiotic relationships and tip the balance …

In recent decades, the incidence and diagnosis of thyroid cancer have risen dramatically,
and thyroid cancer has now become the most common endocrine cancer in the world. The …

Proinflammatory cytokines play a causal role in the development of hyperinsulinemia and
T2MD. FOXO1, a transcription factor which is known to enhance proinflammation, was …