Tumor mutational burden (TMB) reflects cancer mutation quantity. Mutations are processed
to neo-antigens and presented by major histocompatibility complex (MHC) proteins to T …

An updated World Health Organization (WHO) classification of female genital tumours was
published in autumn 2020. We discuss the major new additions to and changes from the …

The SWI/SNF chromatin remodeling complex, via nucleosome topology modulation,
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …

Ovarian carcinoma is characterized by heterogeneity at the molecular, cellular and
anatomical levels, both spatially and temporally. This heterogeneity affects response to …

SMARCA4, also known as transcription activator, is an ATP-dependent catalytic subunit of
SWI/SNF (SWItch/Sucrose NonFermentable) chromatin-remodeling complexes that …

Childhood malignancies are rarely related to known environmental exposures, and it has
become increasingly evident that inherited genetic factors play a substantial causal role …

Atypical teratoid/rhabdoid tumors (ATRTs) are very aggressive childhood malignancies of
the central nervous system. The underlying genetic cause are inactivating bi-allelic …

Cancer is a complex disease in which several molecular and cellular pathways converge to
foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks,“ …

Undifferentiated carcinoma of the gastrointestinal tract has variable rhabdoid features.
Expression of switch/sucrose nonfermenting (SWI/SNF) complex subunits is reportedly lost …

Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2
characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of …