Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application

AML Seca, DCGA Pinto - International journal of molecular sciences, 2018 - mdpi.com
Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and
is one of the leading causes of mortality. The cases reported and the predictions for the near …

Betulin and its derivatives as novel compounds with different pharmacological effects

S Amiri, S Dastghaib, M Ahmadi, P Mehrbod… - Biotechnology …, 2020 - Elsevier
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

Birch bark research and development

PA Krasutsky - Natural product reports, 2006 - pubs.rsc.org
Covering: 1995 to 2006 This review will detail progress made in the previous decade on the
chemistry and bioactivity of birch bark extractive products. Current and future applications of …

Betulinic acid and its derivatives as potential antitumor agents

DM Zhang, HG Xu, L Wang, YJ Li… - Medicinal research …, 2015 - Wiley Online Library
Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously
throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities …

Structural diversity, fermentation production, bioactivities and applications of triterpenoids from several common medicinal fungi: Recent advances and future …

P Zhao, M Guan, W Tang, N Walayat, Y Ding, J Liu - Fitoterapia, 2023 - Elsevier
Medicinal fungi are beneficial to human health and it reduces the risk of chronic diseases.
Triterpenoids are polycyclic compounds derived from the straight-chain hydrocarbon …

Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents

C Gauthier, J Legault, M Lebrun, P Dufour… - Bioorganic & Medicinal …, 2006 - Elsevier
The weak hydrosolubility of betulinic acid (3) hampers the clinical development of this
natural anticancer agent. In order to circumvent this problem and to enhance the …

Synthesis and structure–activity relationship study of cytotoxic germanicane-and lupane-type 3β-O-monodesmosidic saponins starting from betulin

D Thibeault, C Gauthier, J Legault, J Bouchard… - Bioorganic & medicinal …, 2007 - Elsevier
Germanicane-type triterpenes allobetulin (3) and 28-oxoallobetulin (4) can be obtained by
the Wagner-Meerwein rearrangement of the more available lupane-type triterpenes betulin …

Betulinic acid in the treatment of breast cancer: Application and mechanism progress

H Mu, Y Sun, B Yuan, Y Wang - Fitoterapia, 2023 - Elsevier
Betulinic acid (BA) is a pentacyclic triterpene compound, which can be obtained by
separation, chemical synthesis and biotransformation. BA has excellent biological activities …

Secondary metabolites, their structural diversity, bioactivity, and ecological functions: An overview

BM Abegaz, HH Kinfe - Physical Sciences Reviews, 2019 - degruyter.com
Natural products are also called secondary metabolites to distinguish them from the primary
metabolites, ie those natural compounds like glucose, amino acids, etc. that are present in …

A practical synthesis of betulinic acid

R Csuk, K Schmuck, R Schäfer - Tetrahedron letters, 2006 - Elsevier
A new synthetic route for the synthesis of betulinic acid from betulin has been developed.
The main step of this procedure is the selective oxidation of the primary alcohol function of …