Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application
AML Seca, DCGA Pinto - International journal of molecular sciences, 2018 - mdpi.com
Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and
is one of the leading causes of mortality. The cases reported and the predictions for the near …
is one of the leading causes of mortality. The cases reported and the predictions for the near …
Betulin and its derivatives as novel compounds with different pharmacological effects
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …
which possess a wide range of pharmacological activities. Recent evidence indicates that B …
Birch bark research and development
PA Krasutsky - Natural product reports, 2006 - pubs.rsc.org
Covering: 1995 to 2006 This review will detail progress made in the previous decade on the
chemistry and bioactivity of birch bark extractive products. Current and future applications of …
chemistry and bioactivity of birch bark extractive products. Current and future applications of …
Betulinic acid and its derivatives as potential antitumor agents
Betulinic acid (BA) is a lupane‐type pentacyclic triterpene, distributed ubiquitously
throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities …
throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities …
Structural diversity, fermentation production, bioactivities and applications of triterpenoids from several common medicinal fungi: Recent advances and future …
Medicinal fungi are beneficial to human health and it reduces the risk of chronic diseases.
Triterpenoids are polycyclic compounds derived from the straight-chain hydrocarbon …
Triterpenoids are polycyclic compounds derived from the straight-chain hydrocarbon …
Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents
C Gauthier, J Legault, M Lebrun, P Dufour… - Bioorganic & Medicinal …, 2006 - Elsevier
The weak hydrosolubility of betulinic acid (3) hampers the clinical development of this
natural anticancer agent. In order to circumvent this problem and to enhance the …
natural anticancer agent. In order to circumvent this problem and to enhance the …
Synthesis and structure–activity relationship study of cytotoxic germanicane-and lupane-type 3β-O-monodesmosidic saponins starting from betulin
D Thibeault, C Gauthier, J Legault, J Bouchard… - Bioorganic & medicinal …, 2007 - Elsevier
Germanicane-type triterpenes allobetulin (3) and 28-oxoallobetulin (4) can be obtained by
the Wagner-Meerwein rearrangement of the more available lupane-type triterpenes betulin …
the Wagner-Meerwein rearrangement of the more available lupane-type triterpenes betulin …
Betulinic acid in the treatment of breast cancer: Application and mechanism progress
H Mu, Y Sun, B Yuan, Y Wang - Fitoterapia, 2023 - Elsevier
Betulinic acid (BA) is a pentacyclic triterpene compound, which can be obtained by
separation, chemical synthesis and biotransformation. BA has excellent biological activities …
separation, chemical synthesis and biotransformation. BA has excellent biological activities …
Secondary metabolites, their structural diversity, bioactivity, and ecological functions: An overview
Natural products are also called secondary metabolites to distinguish them from the primary
metabolites, ie those natural compounds like glucose, amino acids, etc. that are present in …
metabolites, ie those natural compounds like glucose, amino acids, etc. that are present in …
A practical synthesis of betulinic acid
R Csuk, K Schmuck, R Schäfer - Tetrahedron letters, 2006 - Elsevier
A new synthetic route for the synthesis of betulinic acid from betulin has been developed.
The main step of this procedure is the selective oxidation of the primary alcohol function of …
The main step of this procedure is the selective oxidation of the primary alcohol function of …