Atrial fibrillation and heart failure with reduced ejection fraction are increasing in prevalence
worldwide. Atrial fibrillation can precipitate and can be a consequence of heart failure with …

The prevalence of atrial fibrillation (AF) is increasing as the population ages. AF treatment-
related complications also increase markedly in older adults (defined as≥ 75 years of age …

Aims To analyse the safety and efficacy of direct oral anticoagulants (DOACs) in real-world
studies including atrial fibrillation (AF) patients. Methods and results Systematic review and …

Background and Objectives Ischemic stroke despite a direct oral anticoagulant (DOAC) is
increasingly common and portends a high risk of subsequent ischemic stroke. The efficacy …

Background: Patients with heart failure and atrial fibrillation are an important atrial fibrillation
subgroup in which direct oral anticoagulants (DOACs) have not been adequately studied in …

Randomized controlled trials (RCTs) are preferred by payers for health technology
assessments and coverage decisions. However, the inclusion of a highly selective patient …

Background: There is a plethora of real-world data on the safety and effectiveness of direct-
acting oral anticoagulants (DOACs); however, study heterogeneity has contributed to …

Purpose: To systematically review available evidence of indirect comparisons from RCTs
and direct comparisons from observational studies regarding the comparative effectiveness …

The treatment of acute coronary syndrome (ACS) in elderly patients continues to be a
challenge because of the characteS. GB ristics of this population and the lack of data and …

Background Patient prevalence of atrial fibrillation (AF) and heart failure (HF) is increasing,
and anticoagulation for patients from heterogeneous backgrounds with both conditions …