The development of heterocyclic derivatives has progressed considerably over the past few
decades, and many new agents of synthetic and natural origin have been produced. Among …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Background Hyperuricemia is a putative risk factor for the progression of chronic kidney
disease (CKD). We hypothesized that control of asymptomatic hyperuricemia may slow …

Whether asymptomatic hyperuricemia in the absence of comorbidities increases the risk for
cardiometabolic disorders and chronic kidney disease remains controversial. This study was …

We propose that excessive fructose intake (> 50 g/d) may be one of the underlying etiologies
of metabolic syndrome and type 2 diabetes. The primary sources of fructose are sugar …

The prevalence of chronic kidney disease (CKD) has increased and will continue to
increase in the United States and worldwide. This is alarming considering that CKD is an …

Mesoamerican nephropathy (MeN), an epidemic in Central America, is a chronic kidney
disease of unknown cause. In this article, we argue that MeN may be a uric acid disorder …

Background Non-randomized studies suggest an association between serum uric acid
levels and progression of chronic kidney disease (CKD). The aim of this systematic review is …

Background Hyperuricemia may contribute to renal injury. We do not know whether use of
treatments that lower urate reduce the progression of chronic kidney disease (CKD) and …