Bacteria occupy a diverse set of environmental niches with differing oxygen availability.
Anaerobic environments such as mammalian digestive tracts and industrial reactors harbor …

The physiological roles of endogenous carbon monoxide (CO) have not been fully
understood because of the difficulty in preparing a loss-of-function phenotype of this …

Bilirubin (BR) is a de novo synthesized metabolite of human cells. However, subcellular
localization of BR in the different organelles of human cells has been largely unknown …

Background Bilirubin is a catabolic product of heme metabolism that circulates in the
bloodstream in its unconjugated or glucuronide-conjugated form. Because the accumulation …

The bacterial second messenger cyclic di-GMP (c-di-GMP) holds a prominent position within
the repertoire of bacterial signaling molecules. With its presence established in over 75% of …

ヘム鉄はヘモグロビン, シトクロム c, P450 などのヘムタンパク質において, 酸素が関わる反応や
電子移動などの活性中心としてよく知られているが, 近年,(1) ヘム鉄がシグナル分子になって …