New perspectives on the treatment of hidradenitis suppurativa

V Amat-Samaranch, E Agut-Busquet… - … in Chronic Disease, 2021 - journals.sagepub.com
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the
presence of painful nodules, abscesses, chronically draining fistulas, and scarring in …

Current medical and surgical treatment of hidradenitis suppurativa—a comprehensive review

L Ocker, N Abu Rached, C Seifert, C Scheel… - Journal of Clinical …, 2022 - mdpi.com
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with
recurrent inflammatory lesions in intertriginous body regions. HS has a pronounced impact …

Secukinumab in moderate-to-severe hidradenitis suppurativa (SUNSHINE and SUNRISE): week 16 and week 52 results of two identical, multicentre, randomised …

AB Kimball, GBE Jemec, A Alavi, Z Reguiai, AB Gottlieb… - The Lancet, 2023 - thelancet.com
Background Few therapeutic options are available for patients with moderate-to-severe
hidradenitis suppurativa. We aimed to assess the efficacy of secukinumab in patients with …

Efficacy and safety of adalimumab in conjunction with surgery in moderate to severe hidradenitis suppurativa: the SHARPS randomized clinical trial

FG Bechara, M Podda, EP Prens, B Horváth… - JAMA …, 2021 - jamanetwork.com
Importance Surgery is a mainstay in the management of hidradenitis suppurativa (HS).
Adalimumab is the first drug approved for HS. Objective To investigate the efficacy and …

Guidelines of care for the management of acne vulgaris

RV Reynolds, H Yeung, CE Cheng… - Journal of the American …, 2024 - Elsevier
Background Acne vulgaris commonly affects adults, adolescents, and preadolescents aged
9 years or older. Objective The objective of this study was to provide evidence-based …

Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa

L Jin, Y Chen, S Muzaffar, C Li… - Proceedings of the …, 2023 - National Acad Sciences
Hidradenitis suppurativa (HS) is a complex inflammatory skin disease with undefined
mechanistic underpinnings. Here, we investigated HS epithelial cells and demonstrated that …

[HTML][HTML] Immunopathogenesis of hidradenitis suppurativa and response to anti–TNF-α therapy

MM Lowe, HB Naik, S Clancy, M Pauli, KM Smith, Y Bi… - JCI insight, 2020 - ncbi.nlm.nih.gov
Hidradenitis suppurativa (HS) is a highly prevalent, morbid inflammatory skin disease with
limited treatment options. The major cell types and inflammatory pathways in skin of patients …

New and emerging targeted therapies for hidradenitis suppurativa

A Markota Čagalj, B Marinović… - International journal of …, 2022 - mdpi.com
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease deriving
from the hair follicles. The formation of inflammatory nodules, abscesses, fistulas, and sinus …

The role of hormones in hidradenitis suppurativa: a systematic review

N Abu Rached, T Gambichler, JW Dietrich… - International Journal of …, 2022 - mdpi.com
Hidradenitis suppurativa (HS) is a chronic inflammatory disease manifesting in inverse body
regions. In a systematic review, the role of hormones in HS will be presented to better …

The PI3K-Akt-mTOR and associated signaling pathways as molecular drivers of immune-mediated inflammatory skin diseases: update on therapeutic strategy using …

T Roy, ST Boateng, MB Uddin, S Banang-Mbeumi… - Cells, 2023 - mdpi.com
The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …