Increased interest in the underlying pathogenesis of primary lateral sclerosis (PLS) and its
relationship to amyotrophic lateral sclerosis (ALS) has corresponded to a growing number of …

Abstract Primary Lateral Sclerosis (PLS) is an uncommon motor neuron disorder. Despite
the well-recognisable constellation of clinical manifestations, the initial diagnosis can be …

Temporal lobe studies in motor neuron disease overwhelmingly focus on white matter
alterations and cortical grey matter atrophy. Reports on amygdala involvement are …

Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor
neuron disorder associated with considerable clinical disability. Symptoms are typically …

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable paralytic disorder caused by the
progressive death of upper and lower motoneurons. Although numerous strategies have …

Motor neuron diseases encompass a divergent group of conditions with considerable
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …

Abstract Introduction In 2021, the Deutsche Gesellschaft für Neurology published a new
guideline on diagnosis and therapy of motor neuron disorders. Motor neuron disorders affect …

Background: While amyotrophic lateral sclerosis (ALS) is widely recognised as a multi-
network disorder with extensive frontotemporal and cerebellar involvement, sensory …

Introduction Primary lateral sclerosis is a rare neurodegenerative disorder of the upper
motor neurons. Diagnostic criteria have changed considerably over the years, and the …