Aging is an inevitable natural process that impacts every individual, and understanding its
effect on the gut microbiome and dendritic cell (DC) functionality in elderly subjects is …

Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

Older people are at an increased risk of developing respiratory diseases such as chronic
obstructive pulmonary diseases, asthma, idiopathic pulmonary fibrosis or lung infections …

Objectives Traumatic brain injury (TBI) has complex effects on the gastrointestinal tract that
are associated with TBI-related morbidity and mortality. We examined changes in mucosal …

Stem cells are required for lifelong homeostasis and regeneration of tissues and organs in
mammals, but the function of stem cells declines during aging. To preserve stem cells during …

The epithelium has many critical roles in homeostasis, including an essential responsibility
in establishing tissue barriers. In addition to the fundamental role in separating internal from …

Cellular senescence is a pivotal factor contributing to aging and the pathophysiology of age-
related diseases. Despite the presence of inflammation and abnormal immune system …

Background Our previous studies found that autophagy levels in liver and intestinal
segments of naturally aging rats were downregulated, and the expression of pro …

The age-related decline in the ability of the intestinal barrier to maintain selective
permeability can lead to various physiological disturbances. Adherens junctions play a vital …

With advanced age, there are changes in multiple biologic systems 1 including the immune
system. Alterations in innate and adaptive immune cells in the aged have been noted. 2, 3 In …