Pyrazinamide (PZA) is considered to be a pivotal drug to shorten the treatment of both drug-
susceptible and drug-resistant tuberculosis, but its use is challenged by the reliability of drug …

Here, we describe a clinical case of pyrazinamide-resistant (PZA-R) tuberculosis (TB)
reported as PZA-susceptible (PZA-S) by common molecular diagnostics. Phenotypic …

Background China is one of the high-burden countries for multidrug-resistant tuberculosis
(MDR-TB), and pyrazinamide is one of the anti-TB drugs used for the shorter MDR-TB …

Abstract Development of extensively drug resistant (XDR) strains and multidrug resistant
(MDR) in Mycobacterium tuberculosis is caused by an efflux mechanism of antibiotics in the …

The mutations of pnc A gene encoding pyrazinamidase/PZase in Mycobacterium
tuberculosis are often associated with pyrazinamide/PZA resistance. The H and R1 isolates …

Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis and
classified as pulmonary and extrapulmonary based on their site of infection. Antituberculosis …

Despite major antimicrobial therapeutic advancements, widespread use and misuse of
antimicrobial drugs have increased antimicrobial drug resistance, posing a severe danger to …

Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium which causes tuberculosis
(TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant …

S exually transmitted infections (STI) can be caused by pathogens that have been acquired
through sexual activity (1). STIs are the common cause of illness worldwide, and they …

INTRODUCCIÓN…………………………………………....…….………… 1 2. MARCO
TEÓRICO………………………………………….……….…….... 3 2.1. Mycobacterium …