Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint
movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood …

Animal and clinical studies have shown that mesenchymal stem cells (MSCs) play an
important role in cartilage repair. The therapeutic effect of mesenchymal stem cells based …

Osteoarthritis (OA) is an age-related disease, characterized by cartilage degeneration. The
pathogenesis of OA is complicated and the current therapeutic approaches for OA are …

Muscle and bone interact via physical forces and secreted osteokines and myokines.
Physical forces are generated through gravity, locomotion, exercise, and external devices …

In the absence of timely and proper treatments, injuries to articular cartilage (AC) can lead to
cartilage degeneration and ultimately result in osteoarthritis. Regenerative medicine and …

The treatment of irregular bone defects remains a clinical challenge since the current
biomaterials (eg, calcium phosphate bone cement (CPC)) mainly act as inert substitutes …

Abstract Fibroblast growth factor 8 (FGF‐8), also known as androgen‐induced growth factor
(AIGF), is presumed to be a potent mitogenic cytokine that plays important roles in early …

Disorders of chondrocyte differentiation and endochondral osteogenesis are major
underlying factors in skeletal developmental disorders, including tibial dysplasia (TD) …

Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering
approaches are primarily based on collagen type I devices that are associated with …