Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

The treatment (ie therapy and management) of chronic lymphocytic leukemia (ie the
disease) has been improved thanks to the introduction (ie approval) of kinase inhibitors …

The bone marrow microenvironment promotes proliferation and drug resistance in chronic
lymphocytic leukemia (CLL). Although ibrutinib is active in CLL, it is rarely able to clear …

Protein kinase CK2 (also known as Casein Kinase 2) is a serine/threonine kinase composed
of two catalytic subunits (CK2α and/or CK2α′) and two regulatory CK2β subunits. CK2 is …

Simple Summary This manuscript demonstrates how integrated bioinformatic and statistical
reanalysis of publicly available genomic datasets can be utilized to identify molecular …

The knowledge accumulated over the last decade on B‐cell–derived non‐Hodgkin
lymphoma (B‐NHL) pathogenesis has led to the identification of several molecular …

Background: Diffuse Large B Cell Lymphoma (DLBCL) is the most common type of non-
Hodgkin lymphoma which is heterogeneous both clinically and morphologically. Over the …

Abstract The Ser-Thr kinase CK2 plays important roles in sustaining cell survival and
resistance to stress and these functions are exploited by different types of blood tumors. Yet …

Since 1970, the isolated and identified components of Brucea javanica (L.) Merr. have been
known to contain anticancer effects, particularly antileukemic effect. In this study, the …

Mantle cell lymphoma (MCL) is an incurable B cell non-Hodgkin lymphoma, characterized
by frequent relapses. In the last decade, the pro-survival pathways related to BCR signaling …