CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands
J Korbecki, S Grochans, I Gutowska, K Barczak… - International journal of …, 2020 - mdpi.com
CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC
domain that play an important role in immune system cells, such as CD4+ and CD8+ …
domain that play an important role in immune system cells, such as CD4+ and CD8+ …
The cellular origins of cancer-associated fibroblasts and their opposing contributions to pancreatic cancer growth
P Manoukian, M Bijlsma… - Frontiers in cell and …, 2021 - frontiersin.org
Pancreatic tumors are known to harbor an abundant and highly desmoplastic stroma.
Among the various cell types that reside within tumor stroma, cancer-associated fibroblasts …
Among the various cell types that reside within tumor stroma, cancer-associated fibroblasts …
Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models
S Tsai, L McOlash, K Palen, B Johnson, C Duris… - BMC cancer, 2018 - Springer
Background Patient-derived tumor models are the new standard for pre-clinical drug testing
and biomarker discovery. However, the emerging technology of primary pancreatic cancer …
and biomarker discovery. However, the emerging technology of primary pancreatic cancer …
STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models
W Jing, D McAllister, EP Vonderhaar, K Palen… - … for immunotherapy of …, 2019 - Springer
Pancreatic cancer is characterized by an immune suppressive stromal reaction that creates
a barrier to therapy. A murine transgenic pancreatic cancer cell line that recapitulates human …
a barrier to therapy. A murine transgenic pancreatic cancer cell line that recapitulates human …
Fibroblasts in pancreatic cancer: molecular and clinical perspectives
Pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs) are highly
abundant cells in the pancreatic tumor microenvironment (TME) that modulate desmoplasia …
abundant cells in the pancreatic tumor microenvironment (TME) that modulate desmoplasia …
Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications
L Cao, J Wu, X Qu, J Sheng, M Cui, S Liu… - Journal of Experimental …, 2020 - Springer
Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal
adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary …
adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary …
The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma
Y Fu, S Liu, S Zeng, H Shen - Molecular cancer, 2018 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases
worldwide. It is refractory to conventional treatments, and consequently has a documented 5 …
worldwide. It is refractory to conventional treatments, and consequently has a documented 5 …
[HTML][HTML] The role of CXCL chemokine family in the development and progression of gastric cancer
X Chen, R Chen, R Jin, Z Huang - International journal of clinical …, 2020 - ncbi.nlm.nih.gov
The chemokine (CXC motif) ligand (CXCL) family plays an important role in inflammation. In
order to understand the role of CXC chemokine family in carcinogenesis, this study explored …
order to understand the role of CXC chemokine family in carcinogenesis, this study explored …
Defective localization with impaired tumor cytotoxicity contributes to the immune escape of NK cells in pancreatic cancer patients
SA Lim, J Kim, S Jeon, MH Shin, J Kwon… - Frontiers in …, 2019 - frontiersin.org
Tumor-infiltrating lymphocytes (TILs), found in patients with advanced pancreatic ductal
adenocarcinoma (PDAC), are shown to correlate with overall survival (OS) rate. Although …
adenocarcinoma (PDAC), are shown to correlate with overall survival (OS) rate. Although …
[HTML][HTML] STING activated tumor-intrinsic type I interferon signaling promotes CXCR3 dependent antitumor immunity in pancreatic cancer
EP Vonderhaar, NS Barnekow, D McAllister… - Cellular and molecular …, 2021 - Elsevier
Background & Aims Pancreatic ductal adenocarcinoma (PDA) is a lethal chemoresistant
cancer that exhibits early metastatic spread. The highly immunosuppressive PDA tumor …
cancer that exhibits early metastatic spread. The highly immunosuppressive PDA tumor …