[HTML][HTML] Linking the amyloid, tau, and mitochondrial hypotheses of Alzheimer's disease and identifying promising drug targets

Z Fišar - Biomolecules, 2022 - mdpi.com
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

Galantamine-memantine combination as an antioxidant treatment for schizophrenia

MM Koola, SK Praharaj, A Pillai - Current behavioral neuroscience reports, 2019 - Springer
Abstract Purpose of Review The objective of this article is to highlight the potential role of the
galantamine-memantine combination as a novel antioxidant treatment for schizophrenia …

Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide

S Hata, H Saito, T Kakiuchi, D Fukumoto… - EMBO Molecular …, 2023 - embopress.org
We propose a new therapeutic strategy for Alzheimer's disease (AD). Brain peptide p3‐
Alcβ37 is generated from the neuronal protein alcadein β through cleavage of γ‐secretase …

[HTML][HTML] New therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: Participation of caspase independent death factors …

DK Verma, S Gupta, J Biswas, N Joshi, A Singh… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Piracetam, a nootropic drug that has been clinically used for decades but remains enigmatic
due to no distinct understanding of its mechanism of action. The present study aimed to …

Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease

Z Fišar, R Jirák, M Zvěřová, V Setnička, L Habartová… - Clinical …, 2019 - Elsevier
Objectives Altered amyloid metabolism and mitochondrial dysfunction play key roles in the
development of Alzheimer's disease (AD). We asked whether an association exists between …

Estrogenic and anti-amnesic potential of Millettia griffoniana Baill.(Fabaceae) ethanolic extract on scopolamine-induced memory impairment in ovariectomized Wistar …

RN Rebe, JT Lembe, SDG Nyayi… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Dementias including Alzheimer disease (AD) are
three times higher in menopausal women than in men. Phytoestrogens, a group of plant …

Little in vitro effect of remdesivir on mitochondrial respiration and monoamine oxidase activity in isolated mitochondria

Z Fišar, M Ľupták, J Hroudova - Toxicology Letters, 2021 - Elsevier
Remdesivir (RDV) is a novel antiviral drug whose mitochondrial effects are not well known.
In vitro effects of RDV on the mitochondrial respiration, individual respiratory complexes, and …

Interplay between the APOE genotype and possible plasma biomarkers in Alzheimer's disease

M Zverova, E Kitzlerova, Z Fisar, R Jirak… - Current Alzheimer …, 2018 - ingentaconnect.com
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a
complex pathogenesis and a common occurrence of comorbid diseases such as …

Psychotropic and neurological medication effects on mitochondrial complex I and IV in rodent models

L Holper, D Ben-Shachar, JJ Mann - European Neuropsychopharmacology, 2019 - Elsevier
Mitochondrial complex I (NADH-dehydrogenase) and complex IV (cytochrome-c-oxidase)
are reported to be affected by drugs used to treat psychiatric or neurodegenerative diseases …

[HTML][HTML] Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

C Kondak, M Leith, TC Baddeley, RX Santos… - International Journal of …, 2023 - mdpi.com
Tau protein aggregations are important contributors to the etiology of Alzheimer's disease
(AD). Hydromethylthionine (HMT) is a potent inhibitor of tau aggregation in vitro and in vivo …