Microbial rhodopsins are diverse photoreceptive proteins containing a retinal chromophore
and are found in all domains of cellular life and are even encoded in genomes of viruses …

Olfactory receptors (ORs) and down-stream functional signaling molecules adenylyl cyclase
3 (AC3), olfactory G protein α subunit (Gαolf), OR transporters receptor transporter proteins 1 …

Many organisms sense light using rhodopsins, photoreceptive proteins containing a retinal
chromophore. Here we report the discovery, structure and biophysical characterization of …

Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-
specific conformations that activate only subsets of signaling effectors. In this study, to …

The understanding of G-protein coupled receptors (GPCRs) is undergoing a revolution due
to increased information about their signaling and the experimental determination of …

G protein–coupled receptors (GPCRs) are encoded by over 800 genes in the human
genome. Motivated by different scientific rationales, the two classification systems that are …

Investigation by high resolution Transmission Electron Microscopy (HR-TEM) and
Synchrotron-Radiation based micro X-ray fluorescence (SR-μXRF) of diagenesis in …

This paper is the thirty-eighth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2015 …

The unintended modulation of nuclear receptor (NR) activity by drugs can lead to toxicities
amongst the endocrine, gastrointestinal, hepatic cardiovascular, and central nervous …

Despite efforts to understand the mechanism of neuronal cell death, finding effective
therapies for neurodegenerative diseases is still a challenge. Cognitive deficits are often …