Exercise sustains the hallmarks of health

Y Qiu, B Fernández-García, HI Lehmann, G Li… - Journal of sport and …, 2023 - Elsevier
Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …

Mitochondria as a target for mitigating sarcopenia

PM Coen, RV Musci, JM Hinkley, BF Miller - Frontiers in Physiology, 2019 - frontiersin.org
Sarcopenia is the loss of muscle mass, strength, and physical function that is characteristic
of aging. The progression of sarcopenia is gradual but may be accelerated by periods of …

Targeting the molecular & cellular pillars of human aging with exercise

J Goh, E Wong, J Soh, AB Maier… - The FEBS …, 2023 - Wiley Online Library
Biological aging is the main driver of age‐associated chronic diseases. In 2014, the United
States National Institute of Aging (NIA) sponsored a meeting between several investigators …

Limb muscle quality and quantity in elderly adults with dynapenia but not sarcopenia: an ultrasound imaging study

KV Chang, WT Wu, KC Huang, WH Jan… - Experimental gerontology, 2018 - Elsevier
Background Dynapenia is prevalent in people with reduced skeletal muscle mass, ie
sarcopenia, but a certain population develops muscle strength loss despite having normal …

The emerging roles of protein homeostasis‐governing pathways in Alzheimer's disease

J Cheng, BJ North, T Zhang, X Dai, K Tao, J Guo… - Aging cell, 2018 - Wiley Online Library
Pathways governing protein homeostasis are involved in maintaining the structural,
quantitative, and functional stability of intracellular proteins and involve the ubiquitin …

[HTML][HTML] Zinc at the crossroads of exercise and proteostasis

JD Hernández-Camacho, C Vicente-García… - Redox biology, 2020 - Elsevier
Zinc is an essential element for all forms of life, and one in every ten human proteins is a
zinc protein. Zinc has catalytic, structural and signalling functions and its correct …

Circulating MicroRNA-486 and MicroRNA-146a serve as potential biomarkers of sarcopenia in the older adults

HC Liu, DS Han, CC Hsu, JS Wang - BMC geriatrics, 2021 - Springer
Background: Age-related sarcopenia meaningfully increases the risks of functional
limitations and mortality in the older adults. Although circulating microRNAs (c-miRNAs) are …

Exercise-induced mitohormesis for the maintenance of skeletal muscle and healthspan extension

RV Musci, KL Hamilton, MA Linden - Sports, 2019 - mdpi.com
Oxidative damage is one mechanism linking aging with chronic diseases including the
progressive loss of skeletal muscle mass and function called sarcopenia. Thus, mitigating …

Six weeks of low-load blood flow restricted and high-load resistance exercise training produce similar increases in cumulative myofibrillar protein synthesis and …

P Sieljacks, J Wang, T Groennebaek, E Rindom… - Frontiers in …, 2019 - frontiersin.org
Purpose: High-load resistance exercise contributes to maintenance of muscle mass, muscle
protein quality, and contractile function by stimulation of muscle protein synthesis (MPS) …

A practical perspective on how to develop, implement, execute, and reproduce high‐resolution respirometry experiments: The physiologist's guide to an Oroboros O2k

MA Walsh, RV Musci, RA Jacobs… - The FASEB …, 2023 - Wiley Online Library
The development of high‐resolution respirometry (HRR) has greatly expanded the analytical
scope to study mitochondrial respiratory control relative to specific tissue/cell types across …