Connectome-constrained networks predict neural activity across the fly visual system

JK Lappalainen, FD Tschopp, S Prakhya, M McGill… - Nature, 2024 - nature.com
We can now measure the connectivity of every neuron in a neural circuit,,,,,,,–, but we cannot
measure other biological details, including the dynamical characteristics of each neuron …

Retinal waves prime visual motion detection by simulating future optic flow

X Ge, K Zhang, A Gribizis, AS Hamodi, AM Sabino… - Science, 2021 - science.org
INTRODUCTION Fundamental circuit features of the mouse visual system emerge before
the onset of vision, allowing the mouse to perceive objects and detect visual motion …

[HTML][HTML] Neocortex saves energy by reducing coding precision during food scarcity

Z Padamsey, D Katsanevaki, N Dupuy, NL Rochefort - Neuron, 2022 - cell.com
Information processing is energetically expensive. In the mammalian brain, it is unclear how
information coding and energy use are regulated during food scarcity. Using whole-cell …

A functionally ordered visual feature map in the Drosophila brain

NC Klapoetke, A Nern, EM Rogers, GM Rubin… - Neuron, 2022 - cell.com
Topographic maps, the systematic spatial ordering of neurons by response tuning, are
common across species. In Drosophila, the lobula columnar (LC) neuron types project from …

Simultaneous multi-plane imaging of neural circuits

W Yang, JK Miller, L Carrillo-Reid, E Pnevmatikakis… - Neuron, 2016 - cell.com
Recording the activity of large populations of neurons is an important step toward
understanding the emergent function of neural circuits. Here we present a simple …

Single-cell–initiated monosynaptic tracing reveals layer-specific cortical network modules

A Wertz, S Trenholm, K Yonehara, D Hillier, Z Raics… - Science, 2015 - science.org
Individual cortical neurons can selectively respond to specific environmental features, such
as visual motion or faces. How this relates to the selectivity of the presynaptic network across …

The emergence of directional selectivity in the visual motion pathway of Drosophila

JA Strother, ST Wu, AM Wong, A Nern, EM Rogers… - Neuron, 2017 - cell.com
The perception of visual motion is critical for animal navigation, and flies are a prominent
model system for exploring this neural computation. In Drosophila, the T4 cells of the …

Timing rules for synaptic plasticity matched to behavioral function

A Suvrathan, HL Payne, JL Raymond - Neuron, 2016 - cell.com
It is widely assumed that the complexity of neural circuits enables them to implement diverse
learning tasks using just a few generic forms of synaptic plasticity. In contrast, we report that …

Altered cortical ensembles in mouse models of schizophrenia

JP Hamm, DS Peterka, JA Gogos, R Yuste - Neuron, 2017 - cell.com
In schizophrenia, brain-wide alterations have been identified at the molecular and cellular
levels, yet how these phenomena affect cortical circuit activity remains unclear. We studied …

[HTML][HTML] Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits

D Linaro, B Vermaercke, R Iwata, A Ramaswamy… - Neuron, 2019 - cell.com
How neural circuits develop in the human brain has remained almost impossible to study at
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …