Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P Xie - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

The microbiota-gut-brain axis: from motility to mood

KG Margolis, JF Cryan, EA Mayer - Gastroenterology, 2021 - Elsevier
The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and
extrinsic factors influence signaling along this axis, modulating the function of both the …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial

P Tian, Y Chen, H Zhu, L Wang, X Qian, R Zou… - Brain, behavior, and …, 2022 - Elsevier
Objective Psychobiotics, as a novel class of probiotics mainly acting on the gut-brain axis,
have shown promising prospects in treating psychiatric disorders. Bifidobacterium breve …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

Gut–brain axis: role of gut microbiota on neurological disorders and how probiotics/prebiotics beneficially modulate microbial and immune pathways to improve brain …

K Suganya, BS Koo - International journal of molecular sciences, 2020 - mdpi.com
The gut microbiome acts as an integral part of the gastrointestinal tract (GIT) that has the
largest and vulnerable surface with desirable features to observe foods, nutrients, and …

Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials

RT Liu, RFL Walsh, AE Sheehan - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
With growing interest in the gut microbiome, prebiotics and probiotics have received
considerable attention as potential treatments for depression and anxiety. We conducted a …

The role of gut microbiota in anxiety, depression, and other mental disorders as well as the protective effects of dietary components

RG Xiong, J Li, J Cheng, DD Zhou, SX Wu, SY Huang… - Nutrients, 2023 - mdpi.com
The number of individuals experiencing mental disorders (eg, anxiety and depression) has
significantly risen in recent years. Therefore, it is essential to seek prevention and treatment …

Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat

H Li, Y Xiang, Z Zhu, W Wang, Z Jiang, M Zhao… - Journal of …, 2021 - Springer
Background Chronic unpredictable mild stress (CUMS) can not only lead to depression-like
behavior but also change the composition of the gut microbiome. Regulating the gut …

The gut–brain axis and the microbiome: mechanisms and clinical implications

V Osadchiy, CR Martin, EA Mayer - Clinical Gastroenterology and …, 2019 - Elsevier
Background & Aims Based largely on results from preclinical studies, the concept of a brain
gut microbiome axis has been established, mediating bidirectional communication between …