Hypoxia is a persistent physiological feature of many different solid tumors and a key driver
of malignancy, and in recent years, it has been recognized as an important target for cancer …

Hypoxia, even at non-lethal levels, is one of the most stressful events for all aerobic
organisms as it significantly affects a wide spectrum of physiological functions and energy …

The lack of knowledge about the effect of inspiratory hyperoxia on the lung-specific tumour
microenvironment and progression of lung cancer has attracted considerable attention. This …

OBJECTIVE: Among other types of cancerous lesions, lung cancer is one of the prevalent
causes of death. Trigonelline is a plant alkaloid, a significant constituent in coffee, and has …

Cisplatin, carboplatin, and oxaliplatin are the common platinum-based anticancer drugs
widely used in the chemotherapeutic treatment of solid tumors in clinic. However, the …

Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults.
The mainstay of management for GBM is surgical resection, radiation (RT), and …

Oxygenation conditions are crucial for growth and tumor progression. Recent data suggests
a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia …

The occurrence of hypoxia is common in many solid tumors, and it enhances aggressive
features of cancer such as cell survival, angiogenesis, and metastasis while minimizing the …

Background Lung cancer has risen to the top of the list of cancer‐related deaths worldwide.
Aliskiren is a direct renin inhibitor. Aim This study aims to investigate the impact of cell …

Simple Summary The local conditions of tumor cell growth, known as the tumor
microenvironment (TME), are characterized by low oxygen supply (hypoxia) caused by …