Dynamics of driven polymer transport through a nanopore

K Chen, I Jou, N Ermann, M Muthukumar, UF Keyser… - Nature Physics, 2021 - nature.com
The transport of polymers across nanoscale pores underpins many biological processes,
such as the ejection of bacteriophage DNA into a host cell and the transfer of genes …

Polymer translocation into cavities: Effects of confinement geometry, crowding, and bending rigidity on the free energy

JM Polson, DR Heckbert - Physical Review E, 2019 - APS
Monte Carlo simulations are used to study the translocation of a polymer into a cavity.
Modeling the polymer as a hard-sphere chain with a length up to N= 601 monomers, we use …

Role of DNA–DNA sliding friction and nonequilibrium dynamics in viral genome ejection and packaging

M Fizari, N Keller, PJ Jardine… - Nucleic acids research, 2023 - academic.oup.com
Many viruses eject their DNA via a nanochannel in the viral shell, driven by internal forces
arising from the high-density genome packing. The speed of DNA exit is controlled by friction …

Effects of packaging history on the ejection of a polymer chain from a small confinement

CB Park, BJ Sung - Macromolecules, 2021 - ACS Publications
Polymer chains in various biological and material processes are subject to repetitive cycles
of packaging and ejection via small confinements. For example, a DNA is packaged into and …

Polymer translocation into and out of an ellipsoidal cavity

JM Polson - The Journal of Chemical Physics, 2015 - pubs.aip.org
Monte Carlo simulations are used to study the translocation of a polymer into and out of an
ellipsoidal cavity through a narrow pore. We measure the polymer free energy F as a …

Packing and ejection dynamics of polymers: Role of confinement, polymer stiffness and activity

G Upadhyay, R Kapri, AK Dasanna… - arXiv preprint arXiv …, 2024 - arxiv.org
The translocation of biopolymers, such as DNA and proteins, across cellular or nuclear
membranes is essential for numerous biological processes. The translocation dynamics are …

Relationship between the genome packing in the bacteriophage capsid and the kinetics of DNA ejection

M De Frutos, A Leforestier, F Livolant - Biophysical Reviews and …, 2014 - World Scientific
We present a general survey of experimental and theoretical observations of DNA structure
and in vitro ejection kinetics for different bacteriophage species. In some species, like T5, the …

Rigidity-induced scale invariance in polymer ejection from capsid

RP Linna, PM Suhonen, J Piili - Physical Review E, 2017 - APS
While the dynamics of a fully flexible polymer ejecting a capsid through a nanopore has
been extensively studied, the ejection dynamics of semiflexible polymers has not been …

Can changes in temperature or ionic conditions modify the DNA organization in the full bacteriophage capsid?

M Frutos, A Leforestier, J Degrouard… - The Journal of …, 2016 - ACS Publications
We compared four bacteriophage species, T5, λ, T7, and Φ29, to explore the possibilities of
DNA reorganization in the capsid where the chain is highly concentrated and confined. First …

Packaging stiff polymers in small containers: A molecular dynamics study

DC Rapaport - Physical Review E, 2016 - APS
The question of how stiff polymers are able to pack into small containers is particularly
relevant to the study of DNA packaging in viruses. A reduced version of the problem based …