Disordered calcification of cartilage and ligaments occurs commonly amongst the elderly,
yet the reasons for this are very poorly understood. Chondrocalcinosis affects 25% of the …

Calcium pyrophosphate (CPP) crystal deposition (CPPD) is associated with ageing and
osteoarthritis, and with uncommon disorders such as hyperparathyroidism …

Table of contents: I. Structure and function of joints, connective tissue, and muscle. II.
Immune and inflammatory responses. III. Evaluation of the patient. IV. Special issues of the …

Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive
form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint …

Craniometaphyseal dysplasia (CMD) is a bone dysplasia characterized by overgrowth and
sclerosis of the craniofacial bones and abnormal modeling of the metaphyses of the tubular …

Chondrocalcinosis (CC) is a common cause of joint pain and arthritis that is caused by the
deposition of calcium-containing crystals within articular cartilage. Although most cases are …

Mutations in the progressive ankylosis gene (Ank/ANKH) cause surprisingly different
skeletal phenotypes in mice and humans. In mice, recessive loss-of-function mutations …

Familial autosomal dominant calcium pyrophosphate dihydrate (CPPD) chondrocalcinosis
has previously been mapped to chromosome 5p15. We have identified a mutation in the …

To reveal the ANK complete loss of function phenotype in mice, we generated conditional
and null alleles. Mice homozygous for the null allele exhibited widespread joint …

Calcium pyrophosphate disease (CPPD) is caused by the deposition of calcium
pyrophosphate (CPP) crystals in the joint tissues, particularly fibrocartilage and hyaline …