Dissecting the role of subtypes of gastrointestinal vagal afferents

YB Wang, G De Lartigue, AJ Page - Frontiers in Physiology, 2020 - frontiersin.org
Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain.
Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut …

Proposal open for discussion: defining agreed diagnostic procedures in experimental diabetes research

E Matteucci, O Giampietro - Journal of ethnopharmacology, 2008 - Elsevier
BACKGROUND: Animal experimentation has a long tradition in diabetes research and has
provided invaluable benefits with regard to insulin discovery and treatment assessment …

Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation

JV Pardo, SA Sheikh, MA Kuskowski… - International journal of …, 2007 - nature.com
Fourteen patients were treated over 2 years with cervical vagus nerve stimulation (VNS) for
adjunctive therapy of severe, treatment-resistant depression. Here, we report the …

Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat

BP Cummings, EK Digitale… - American Journal …, 2008 - journals.physiology.org
The prevalence of type 2 diabetes (T2DM) is increasing, creating a need for T2DM animal
models for the study of disease pathogenesis, prevention, and treatment. The purpose of this …

Anorexia‐cachexia syndrome in hepatoma tumour‐bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC‐1/GDF15

T Borner, M Arnold, J Ruud, SN Breit… - Journal of cachexia …, 2017 - Wiley Online Library
Background The cancer‐anorexia‐cachexia syndrome (CACS) negatively affects survival
and therapy success in cancer patients. Inflammatory mediators and tumour‐derived factors …

Glucose effectiveness: Lessons from studies on insulin‐independent glucose clearance in mice

B Ahrén, G Pacini - Journal of Diabetes Investigation, 2021 - Wiley Online Library
Besides insulin‐mediated transport of glucose into the cells, an important role is also played
by the non‐insulin‐mediated transport. This latter process is called glucose effectiveness …

Cholecystokinin/Cholecystokinin-1 receptor-mediated peripheral activation of the afferent vagus by enteral nutrients attenuates inflammation in rats

T Lubbers, JJ de Haan, MDP Luyer, I Verbaeys… - Annals of …, 2010 - journals.lww.com
Objective: The current study investigates activation of the nutritional anti-inflammatory
pathway by lipid-rich nutrition. Background: Enteral nutrition activates humoral and neural …

Cervical vagal stimulation induced weight loss

JV Pardo, SA Sheikh - US Patent 8,064,994, 2011 - Google Patents
5,215,086 A 6/1993 Terry, Jr. et al. 5,222.494. A 6/1993 Baker, Jr. 5,231,988 A 8, 1993
Wernicke et al. 5,235,980 A 8, 1993 Varrichio et al. 5,263,480 A 11/1993 Wernicke et al …

[图书][B] Handbook of Laboratory Animal Science: Animal Models, Volume II

J Hau, SJ Schapiro, GL Van Hoosier Jr - 2002 - taylorfrancis.com
The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats [S]

G Schober, M Arnold, S Birtles, LK Buckett… - Journal of lipid …, 2013 - ASBMB
Acyl CoA: diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final step in triacylglycerol
(TAG) synthesis and is highly expressed in the small intestine. Because DGAT-1 knockout …