The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Aging and age-related diseases pose some of the most significant and difficult challenges to
modern society as well as to the scientific and medical communities. Biological aging is a …

Abstract Anti-silencing function 1 (Asf1) and Chromatin Assembly Factor 1 (CAF-1)
chaperone histones H3/H4 during the assembly of nucleosomes on newly replicated DNA …

Tousled-like kinases (TLKs) are nuclear serine-threonine kinases essential for genome
maintenance and proper cell division in animals and plants. A major function of TLKs is to …

Gene duplication is regarded as the main source of adaptive functional novelty in
eukaryotes. Processes such as neo-and subfunctionalization impact the evolution of …

During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to
restore chromatin organization. Asf1, a key histone H3-H4 chaperone required for this …

Abstract ANTI-SILENCING FUNCTION1 (ASF1) isa key histone H3/H4 chaperone that
participates in a variety of DNA-and chromatin-related processes, including DNA repair …

To allow for sufficient time to repair DNA double-stranded breaks (DSBs), eukaryotic cells
activate the DNA damage checkpoint. In budding yeast, Rad53 (mammalian Chk2) …

Many agents used for chemotherapy, such as doxorubicin, interfere with DNA replication,
but the effect of this interference on transcription is largely unknown. Here we show that …

Protein phosphorylation is one of the main mechanisms by which signals are transmitted in
eukaryotic cells, and it plays a crucial regulatory role in almost all cellular processes. In …