Actively targeted gold-polydopamine (PDA@ Au) nanocomplex for sequential drug release and combined synergistic chemo-photothermal therapeutic effects
Multifunctional nanoparticles for treatment in cancer are getting more and more attention
recently. In this study, we employed a novel polydopamine (PDA) framework-based gold …
recently. In this study, we employed a novel polydopamine (PDA) framework-based gold …
Abiraterone Acetate Complexes with Biometals: Synthesis, Characterization in Solid and Solution, and the Nature of Chemical Bonding
Abiraterone acetate (AbirAc) is the most used steroidal therapeutic agent for treatment of
prostate cancer. The mainly hydrophobic molecular surface of AbirAc results in its poor …
prostate cancer. The mainly hydrophobic molecular surface of AbirAc results in its poor …
Pharmaceutical cocrystals: Unlocking the potential of challenging drug candidates
J Pantwalawalkar, N Kale, S Nangare, S Patil… - Journal of Drug Delivery …, 2024 - Elsevier
Pharmaceutical development is often limited by drugs with unfavorable physicochemical
properties, such as poor solubility, limited permeability, and low bioavailability, which …
properties, such as poor solubility, limited permeability, and low bioavailability, which …
A Comprehensive Review on Theoretical Screening Methods for Pharmaceutical Cocrystals
J Roshni, T Karthick - Journal of Molecular Structure, 2025 - Elsevier
In crystal engineering, cocrystallization has become one of the preferred methods for
improving the physicochemical properties of active pharmaceutical ingredients (APIs). The …
improving the physicochemical properties of active pharmaceutical ingredients (APIs). The …
Rational Design of the Carbamazepine Ternary Cocrystals
The first ternary cocrystals of carbamazepine (CBZ) were successfully identified through a
large-scale screening. A design strategy involved the use of an aliphatic dicarboxylic acid to …
large-scale screening. A design strategy involved the use of an aliphatic dicarboxylic acid to …
Unraveling a Unique Metastable Phase of a Proxyphylline Cocrystal Exclusively Produced by Compressed Carbon Dioxide
F Ercicek, M Marchivie, L Nimod, H Cercel… - Crystal Growth & …, 2024 - ACS Publications
In this work, racemic proxyphylline ((±)-PXL, a chiral drug) was cocrystallized for the first time
with 4-hydroxybenzoic acid (4-HBA) from three solvents (acetone, ethyl acetate, and …
with 4-hydroxybenzoic acid (4-HBA) from three solvents (acetone, ethyl acetate, and …
Two novel drug-nutraceutical cocrystal hydrates of carbamazepine: The influence of isomerism in trihydroxybenzoic acids on the in vitro/in vivo properties
Two novel drug-nutraceutical cocrystal hydrates based on the antiepileptic carbamazepine
(CBZ) with isomeric trihydroxybenzoic acids, including 3, 4, 5-trihydroxybenzoic acid …
(CBZ) with isomeric trihydroxybenzoic acids, including 3, 4, 5-trihydroxybenzoic acid …
Structural and vibrational spectral analysis of polymorphs of anhydrous Acyclovir Using terahertz and Raman spectroscopy
Q Zhao, J Zhang, Y Jing, J Xue, J Liu, J Qin, Z Hong… - Chemical Physics, 2025 - Elsevier
Acyclovir (ACV), a prototypical antiviral drug, exhibits distinct physicochemical properties
due to its polymorphism. In this study, two stable anhydrous forms of ACV were prepared at …
due to its polymorphism. In this study, two stable anhydrous forms of ACV were prepared at …
Advances in solvent based cocrystallization: Bridging the gap between theory and practice
A common tactic in materials science and pharmaceuticals is cocrystallization, which
synthesises multi-component crystalline materials with unique physicochemical …
synthesises multi-component crystalline materials with unique physicochemical …
Two crystalline polymorphs of voriconazole− 2, 4− dihydroxybenzoic acid cocrystals
N Gong, Y Zou, S Yang, X Meng, H Yu, G He… - Journal of Molecular …, 2025 - Elsevier
In this work, two novel voriconazole and 2, 4− dihydroxybenzoic acid cocrystal polymorphs
(Form A and B) were harvested using liquid-assisted grinding method with a mortar and …
(Form A and B) were harvested using liquid-assisted grinding method with a mortar and …