Abstract Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that
belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially …

Transforming growth factor betas (TGF-βs) are known as multifunctional growth factors that
participate in the regulation of key events of development, disease, and tissue repair. In the …

Hereditary hemochromatosis, characterized by iron overload in multiple organs, is one of the
most common genetic disorders among Caucasians. Hepcidin, which is synthesized in the …

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout,
knockin, and reporter expression in the mouse nervous system. However, we report varying …

Signaling by the transforming growth factor β (TGF-β) family is necessary for proper neural
development and function throughout life. Sequential waves of activation, inhibition, and …

Genetic and biochemical data have identified Smad4 as a key intracellular effector of the
transforming growth factor β (TGFβ superfamily of secreted ligands. In mouse, Smad4-null …

In the adult brain, the expression of NT-3 is largely confined to the hippocampal dentate
gyrus (DG), an area exhibiting significant neurogenesis. Using a conditional mutant line in …

Cholangiocellular carcinoma (CC), the second most common primary liver cancer, is
associated with a poor prognosis. It has been shown that CCs harbor alterations of a …

Transforming growth factor–β (TGF-β) and TGF-β–related proteins, such as the bone
morphogenetic proteins, have emerged as key regulators of stem cell renewal and …

Transforming growth factor betas (TGF-βs) are known as multifunctional growth factors,
which participate in the regulation of key events of development, disease and tissue repair …