Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

The obesity epidemic has been widely publicized in the media worldwide. Investigators at all
levels have been looking for factors that have contributed to the development of this …

Ghrelin is brain-gut peptide with growth hormone-releasing and appetite-inducing activities.
It is mainly secreted from the stomach mucosa but it is also expressed widely in different …

Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and
subsequent food intake. The ghrelinergic system has therefore received considerable …

To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically
sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore …

Increases in arousal and activity in anticipation of a meal, termed “food anticipatory
activity”(FAA), depend on circadian food-entrainable oscillators (FEOs), whose locations and …

Here we review recent advances that identify a role for the central ghrelin signalling system
in reward from both natural rewards (such as food) and artificial rewards (that include …

A breakthrough using “reverse pharmacology” identified and characterized acyl ghrelin from
the stomach as the endogenous cognate ligand for the growth hormone (GH) secretagogue …

Neuropeptide Y (NPY) is a highly conserved neuropeptide with orexigenic actions in
discrete hypothalamic nuclei that plays a role in regulating energy homeostasis. NPY …