Major depressive disorder (MDD) is a prevalent psychiatric disease that involves
malfunctions of different cell types in the brain. Accumulating studies started to reveal that …

Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Enhanced bursting activity of neurons in the lateral habenula (LHb) is essential in driving
depression-like behaviours, but the cause of this increase has been unknown. Here, using a …

Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …

Inflammation and depression are closely inter-related; inflammation induces symptoms of
depression and, conversely, depressed mood and stress favor an inflammatory phenotype …

As is reported, the incidence and prevalence of depression are higher in women than in
men, but the cause of this sex difference remains elusive. Although recent studies implicated …

Early life overfeeding is associated with cognitive decline and anxiety-like behaviors in later
life. It is not clear whether there are individual differences in the effects of early life …

Background Neuroinflammation has recently emerged as a critical risk factor in the
pathophysiology of depression. However, the underlying molecular mechanisms and the …

Background Discoveries that microglia-mediated neuroinflammation is involved in the
pathological process of depression provided a new strategy for novel antidepressant …

Mutual regulation and balance between the endocrine and immune systems facilitate an
organism's stress response and are impaired following chronic stress or prolonged immune …