Metabolic engineering strategies for microbial synthesis of oleochemicals

BF Pfleger, M Gossing, J Nielsen - Metabolic engineering, 2015 - Elsevier
Microbial synthesis of oleochemicals has advanced significantly in the last decade.
Microbes have been engineered to convert renewable substrates to a wide range of …

Natural products as biofuels and bio-based chemicals: fatty acids and isoprenoids

HR Beller, TS Lee, L Katz - Natural product reports, 2015 - pubs.rsc.org
Covering: 2005 to 2015 Although natural products are best known for their use in medicine
and agriculture, a number of fatty acid-derived and isoprenoid natural products are being …

Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol

J Gao, Y Li, W Yu, YJ Zhou - Nature Metabolism, 2022 - nature.com
Methanol is an ideal feedstock for biomanufacturing that can be beneficial for global carbon
neutrality; however, the toxicity of methanol limits the efficiency of methanol metabolism …

[HTML][HTML] Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories

YJ Zhou, NA Buijs, Z Zhu, J Qin, V Siewers… - Nature …, 2016 - nature.com
Sustainable production of oleochemicals requires establishment of cell factory platform
strains. The yeast Saccharomyces cerevisiae is an attractive cell factory as new strains can …

Viscous control of cellular respiration by membrane lipid composition

I Budin, T de Rond, Y Chen, LJG Chan, CJ Petzold… - Science, 2018 - science.org
Lipid composition determines the physical properties of biological membranes and can vary
substantially between and within organisms. We describe a specific role for the viscosity of …

Comprehensive in Vitro Analysis of Acyltransferase Domain Exchanges in Modular Polyketide Synthases and Its Application for Short-Chain Ketone Production

S Yuzawa, K Deng, G Wang, EEK Baidoo… - ACS synthetic …, 2017 - ACS Publications
Type I modular polyketide synthases (PKSs) are polymerases that utilize acyl-CoAs as
substrates. Each polyketide elongation reaction is catalyzed by a set of protein domains …

Engineering high-level production of fatty alcohols by Saccharomyces cerevisiae from lignocellulosic feedstocks

L d'Espaux, A Ghosh, W Runguphan, M Wehrs… - Metabolic …, 2017 - Elsevier
Fatty alcohols in the C12-C18 range are used in personal care products, lubricants, and
potentially biofuels. These compounds can be produced from the fatty acid pathway by a …

Metabolic engineering of microalgal based biofuel production: prospects and challenges

C Banerjee, KK Dubey, P Shukla - Frontiers in microbiology, 2016 - frontiersin.org
The current scenario in renewable energy is focused on development of alternate and
sustainable energy sources, amongst which microalgae stands as one of the promising …

Converting sugars to biofuels: ethanol and beyond

A Kang, TS Lee - Bioengineering, 2015 - mdpi.com
To date, the most significant sources of biofuels are starch-or sugarcane-based ethanol,
which have been industrially produced in large quantities in the USA and Brazil …

Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids

AQ Yu, NKP Juwono, JL Foo, SSJ Leong… - Metabolic …, 2016 - Elsevier
Short branched-chain fatty acids (SBCFAs, C4-6) are versatile platform intermediates for the
production of value-added products in the chemical industry. Currently, SBCFAs are mainly …