The cinnamamide scaffold has been incorporated in to the structure of numerous organic
compounds with therapeutic potential. The scaffold enables multiple interactions, such as …

Positron emission tomography (PET) neuroimaging of ion channel linked receptors is a
developing area of preclinical and clinical research. The present review focuses on recent …

The transient receptor potential vanilloid receptor type–1 (TRPV1) is critically involved in
peripheral nociceptive processes of somatic and visceral pain. However, the role of the …

Transient receptor potential cation channel subfamily V member 1 (TRPV1) was identified
using capsaicin, a pungent compound that is present in red pepper. The activation of TRPV1 …

Over the last half-century, the molecular imaging technique of positron emission tomography
(PET) has emerged as an important tool for biomedical research, drug development and …

Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions
with various nucleophilic amines. Strategically placed second functionality allows for the …

The transient receptor potential vanilloid type 1 (TRPV1), a non-selective cation channel, is
known for its essential role in the pathogenesis of various pain conditions such as nerve …

The endocannabinoid system consists of cannabinoid receptors (which mediate the actions
of cannabis), their endogenous ligands (endocannabinoids), and the enzymes and proteins …

The purpose of this study was to synthesize a new positron emission tomography
radiotracer, N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine-1 (2H)-[11 …

Neuropathic pain is a chronic disability associated with a dysfunction of the nervous system,
initiated by a primary lesion or disease. Even after resolution of the initiating pathology …