The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

RNA interference (RNAi) was discovered less than a decade ago and already there are
human clinical trials in progress or planned. A major advantage of RNAi versus other …

MicroRNAs are small RNA molecules that regulate messenger RNA (mRNA) expression.
MicroRNA 122 (miR-122) is specifically expressed and highly abundant in the human liver …

Hepatitis C virus (HCV) infection causes chronic liver diseases and is a global public health
problem. Detailed analyses of HCV have been hampered by the lack of viral culture …

Many RNA viruses remodel intracellular membranes to generate specialized sites for RNA
replication. How membranes are remodeled and what properties make them conducive for …

The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely
limited analysis of the HCV life cycle and the development of effective antivirals and …

Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …

In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …

The discovery of RNA interference (RNAi) may well be one of the transforming events in
biology in the past decade. RNAi can result in gene silencing or even in the expulsion of …

Chronic liver disease caused by infection with hepatitis C virus (HCV) is an important global
health problem that currently affects 170 million people. A major impediment in HCV …