Dopamine and levodopa prodrugs for the treatment of Parkinson's disease
F Haddad, M Sawalha, Y Khawaja, A Najjar… - Molecules, 2017 - mdpi.com
Background: Parkinson's disease is an aggressive and progressive neurodegenerative
disorder that depletes dopamine (DA) in the central nervous system. Dopamine replacement …
disorder that depletes dopamine (DA) in the central nervous system. Dopamine replacement …
[HTML][HTML] Recent advances in drug delivery systems
N Martinho, C Damgé, CP Reis - Journal of biomaterials and …, 2011 - scirp.org
Drug targeting to specific organs and tissues has become one of the critical endeavors of the
century since the use of free drugs in conventional dosage forms generally involves …
century since the use of free drugs in conventional dosage forms generally involves …
[HTML][HTML] An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
Neurological diseases are responsible for a large number of morbidities and mortalities in
the world. Flavonoids are phytochemicals that possess various health-promoting impacts …
the world. Flavonoids are phytochemicals that possess various health-promoting impacts …
Permeability of the blood–brain barrier: molecular mechanism of transport of drugs and physiologically important compounds
CW Fong - The Journal of membrane biology, 2015 - Springer
A new molecular model for the permeability of drugs and other physiologically important
compounds to cross the blood–brain barrier has been developed. Permeability (log PS) is …
compounds to cross the blood–brain barrier has been developed. Permeability (log PS) is …
Nanotechnology-based drug delivery systems for targeting, imaging and diagnosis of neurodegenerative diseases
S Bozdağ Pehlivan - Pharmaceutical research, 2013 - Springer
Neurodegenerative disorders are becoming prevalent with the increasing age of the general
population. A number of difficulties have emerged for the potential treatment of …
population. A number of difficulties have emerged for the potential treatment of …
The “frail” brain blood barrier in neurodegenerative diseases: Role of early disruption of endothelial cell-to-cell connections
J Maiuolo, M Gliozzi, V Musolino, M Scicchitano… - International journal of …, 2018 - mdpi.com
The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular
component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and …
component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and …
Updates on drug designing approach through computational strategies: a review
The drug discovery and development (DDD) process in pursuit of novel drug candidates is a
challenging procedure requiring lots of time and resources. Therefore, computer-aided drug …
challenging procedure requiring lots of time and resources. Therefore, computer-aided drug …
Nanotechnology-based drug delivery for the treatment of CNS disorders
Approximately 6.8 million people die annually because of problems related to the central
nervous system (CNS), and out of them, approximately 1 million people are affected by …
nervous system (CNS), and out of them, approximately 1 million people are affected by …
Advances and challenges in intranasal delivery of antipsychotic agents targeting the central nervous system
Treatment of central nervous system (CNS) disorders is challenging using conventional
delivery strategies and routes of administration because of the presence of the blood–brain …
delivery strategies and routes of administration because of the presence of the blood–brain …
In vitro model for predicting the access and distribution of drugs in the brain using hCMEC/D3 cells
The BBB is a protective entity that prevents external substances from reaching the CNS but it
also hinders the delivery of drugs into the brain when they are needed. The main objective …
also hinders the delivery of drugs into the brain when they are needed. The main objective …