Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …

Inflammasomes are newly recognized, vital players in innate immunity. The best
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …

The rapid increase in metabolic diseases, which occurred in the last three decades in both
industrialized and developing countries, has been related to the rise in sugar-added foods …

The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and
IL-18, and drives a form of cell death known as pyroptosis. Oligomerization of this complex is …

As a promising new target, miR-233 may regulate oxidative stress by targeting keap1-Nrf2
system to affect the pathological process of liver injury in T2DM. Ellagic acid (EA) is versatile …

High dietary fructose is a major contributor to insulin resistance and metabolic syndrome,
disturbing tissue and organ functions. Fructose is mainly absorbed into systemic circulation …

The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin
domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent …

Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2
(TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which …

The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …

Inflammation is a devastating pathophysiological process during stroke, a devastating
disease that is the second most common cause of death worldwide. Activation of the NOD …