Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …

Chronic inflammation including autoimmune disease is an important risk factor for the
development of osteoporosis. Receptor activator of nuclear factor-κB ligand (RANKL) and …

Huntington's disease (HD) is characterized by a progressive course of disease until death
15–20 years after the first symptoms occur and is caused by a mutation with expanded CAG …

In Huntington disease (HD), immune cells are activated before symptoms arise; however, it
is unclear how the expression of mutant huntingtin (htt) compromises the normal functions of …

Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic
alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often …

Psoriasis is a chronic, relapsing, autoimmune disorder of the skin affecting 2–3% of general
population. Approximately 30% of psoriasis patients are also affected with the psoriatic …

MDSCs are a heterogeneous group of myeloid cells that suppress T cell activity in cancer
and autoimmune disease. The effect of MDSCs on B cell function is not clear. Using the CIA …

Objective To determine the role of leptin in modulating Th17 cell response and joint
inflammation in mice with collagen‐induced arthritis (CIA). Methods Leptin receptor …

Rheumatoid arthritis (RA) is a multisystemic and inflammatory autoimmune disease
characterized by joint destruction. The C–C motif chemokine receptor 2 (CCR2) is mainly …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily
affects the joints. Self-reactive B and T lymphocytes cooperate to promote antibody …