[HTML][HTML] The foundation and architecture of precision medicine in neurology and psychiatry
Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …
The complex pathway between amyloid β and cognition: implications for therapy
For decades, the hypothesis that brain deposition of the amyloid β protein initiates
Alzheimer's disease has dominated research and clinical trials. Targeting amyloid β is …
Alzheimer's disease has dominated research and clinical trials. Targeting amyloid β is …
Accuracy of tau positron emission tomography as a prognostic marker in preclinical and prodromal Alzheimer disease: a head-to-head comparison against amyloid …
Importance Tau positron emission tomography (PET) tracers have proven useful for the
differential diagnosis of dementia, but their utility for predicting cognitive change is unclear …
differential diagnosis of dementia, but their utility for predicting cognitive change is unclear …
Biomarker-based prediction of longitudinal tau positron emission tomography in Alzheimer disease
Importance There is currently no consensus as to which biomarkers best predict longitudinal
tau accumulation at different clinical stages of Alzheimer disease (AD). Objective To …
tau accumulation at different clinical stages of Alzheimer disease (AD). Objective To …
Age-related and amyloid-beta-independent tau deposition and its downstream effects
Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial
temporal lobe. However, there is evidence that, independently of Aβ, age-related tau …
temporal lobe. However, there is evidence that, independently of Aβ, age-related tau …
Neuroprotective mechanisms of ginsenoside Rb1 in central nervous system diseases
L Gong, J Yin, Y Zhang, R Huang, Y Lou… - Frontiers in …, 2022 - frontiersin.org
Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical
value in Asian countries, have a long usage history in China for the therapy of some …
value in Asian countries, have a long usage history in China for the therapy of some …
Regional tau deposition reflects different pathways of subsequent neurodegeneration and memory decline in cognitively normal older adults
Objective Tau pathology is recognized as a primary contributor to neurodegeneration and
clinical symptoms in Alzheimer's disease (AD). This study aims to localize the early tau …
clinical symptoms in Alzheimer's disease (AD). This study aims to localize the early tau …
Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults
Noninvasive biomarkers of early neuronal injury may help identify cognitively normal
individuals at risk of developing Alzheimer's disease (AD). A recent diffusion-weighted …
individuals at risk of developing Alzheimer's disease (AD). A recent diffusion-weighted …
Genetically identical twins show comparable tau PET load and spatial distribution
EM Coomans, J Tomassen, R Ossenkoppele… - Brain, 2022 - academic.oup.com
Tau accumulation starts during the preclinical phase of Alzheimer's disease and is closely
associated with cognitive decline. For preventive purposes, it is important to identify factors …
associated with cognitive decline. For preventive purposes, it is important to identify factors …
Thioredoxin-1 inhibits amyloid-β25–35-induced activation of NLRP1/caspase-1/GSDMD pyroptotic pathway in PC12 cells
J Jia, X Zhang, G Xu, X Zeng, L Li - Molecular Biology Reports, 2022 - Springer
Background Alzheimer's disease (AD), the most common neurodegenerative disease, is
charactered by these accepted pathological features, such as β-amyloid (Aβ) plaques …
charactered by these accepted pathological features, such as β-amyloid (Aβ) plaques …