Recent advances in the molecular understanding of medulloblastoma

Y Funakoshi, Y Sugihara, A Uneda… - Cancer …, 2023 - Wiley Online Library
Medulloblastoma is the most common pediatric malignant brain tumor composed of four
molecular subgroups. Recent intensive genomics has greatly contributed to our …

Intravital imaging techniques for biomedical and clinical research

A Coste, MH Oktay, JS Condeelis… - Cytometry Part …, 2020 - Wiley Online Library
Intravital imaging, the direct visualization of cells and tissues within a living animal, is a
technique that has been employed for the better part of a century. The advent of confocal …

Childhood cancer mutagenesis caused by transposase-derived PGBD5

M Yamada, RR Keller, RL Gutierrez, D Cameron… - Science …, 2024 - science.org
Genomic rearrangements are a hallmark of most childhood tumors, including
medulloblastoma, one of the most common brain tumors in children, but their causes remain …

Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation

IL Tan, A Wojcinski, H Rallapalli… - Proceedings of the …, 2018 - National Acad Sciences
The main cell of origin of the Sonic hedgehog (SHH) subgroup of medulloblastoma (MB) is
granule cell precursors (GCPs), a SHH-dependent transient amplifying population in the …

Longitudinal manganese‐enhanced magnetic resonance imaging of neural projections and activity

TW Uselman, CS Medina, HB Gray… - NMR in …, 2022 - Wiley Online Library
Manganese‐enhanced magnetic resonance imaging (MEMRI) holds exceptional promise
for preclinical studies of brain‐wide physiology in awake‐behaving animals. The objectives …

[HTML][HTML] Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment

L Tamayo-Orrego, F Charron - F1000Research, 2019 - ncbi.nlm.nih.gov
Medulloblastoma, the most common of the malignant pediatric brain tumors, is a group of
four molecularly and clinically distinct cancers with different cells of origin. One of these …

A cerebellar window for intravital imaging of normal and disease states in mice

V Askoxylakis, M Badeaux, S Roberge, A Batista… - Nature protocols, 2017 - nature.com
The cerebellum is a prominent part of the vertebrate hindbrain that is critically involved in the
regulation of important body functions such as movement coordination, maintenance of …

Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain

CL Brunnquell, R Hernandez… - Contrast media & …, 2016 - Wiley Online Library
Manganese‐enhanced magnetic resonance imaging (MRI) is an established neuroimaging
method for signal enhancement, tract tracing, and functional studies in rodents. Along with …

[HTML][HTML] Histological correlates of diffusion-weighted magnetic resonance microscopy in a mouse model of mesial temporal lobe epilepsy

K Göbel-Guéniot, J Gerlach, R Kamberger… - Frontiers in …, 2020 - frontiersin.org
Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy. It is
frequently associated with abnormal MRI findings, which are caused by underlying cellular …

A mathematical model of granule cell generation during mouse cerebellum development

SR Leffler, E Legué, O Aristizábal, AL Joyner… - Bulletin of mathematical …, 2016 - Springer
Determining the cellular basis of brain growth is an important problem in developmental
neurobiology. In the mammalian brain, the cerebellum is particularly amenable to studies of …