Severe thermal injury, defined as burns encompassing over 40% of a patient's total body
surface area (TBSA), is followed by a pronounced hypermetabolic response that persists for …

A severe burn can trigger a hypermetabolic state which lasts for years following the injury, to
the detriment of the patient. The drastic increase in metabolic demands during this phase …

Objective: To improve clinical outcome and to determine new treatment options, we studied
the pathophysiologic response postburn in a large prospective, single center, clinical trial …

Introduction Severe thermal injury is characterized by profound morbidity and mortality.
Advances in burn and critical care, including early excision and grafting, aggressive …

Outcomes of patients with burns have improved substantially over the past two decades.
Findings from a 2012 study in The Lancet showed that a burn size of more than 60% total …

Hypermetabolism is the ubiquitous response to a severe burn injury, which was first
described in the nineteenth century. Despite identification of important components of this …

Thermal injury produces a profound hypermetabolic and hypercatabolic stress response
characterized by increased endogenous glucose production via gluconeogenesis and …

Severe burn injury is associated with a profound hypermetabolic, hypercatabolic response
proportional to the original size of the injury, which persists for 1 to 2 years postburn. 1, 2 …

Hepatic homeostasis and metabolism are essential for survival in critically ill and severely
burned patients. There is evidence that the liver undergoes hypertrophy after burn. However …

Severe thermal injury, defined as burns encompassing more than 30% of a patient's total
body surface area (TBSA), is followed by a marked and persistent hypermetabolic response …