Insight into the cardioprotective effects of melatonin: shining a spotlight on intercellular Sirt signaling communication

A Yaghoobi, M Rezaee, N Hedayati… - Molecular and Cellular …, 2024 - Springer
Cardiovascular diseases (CVDs) are the leading causes of death and illness worldwide.
While there have been advancements in the treatment of CVDs using medication and …

[HTML][HTML] Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway

W Zhang, X Wang, Y Tang, C Huang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Melatonin confers cardioprotective effects on multiple cardiovascular diseases, including
doxorubicin-induced cardiomyopathy. The effectiveness of melatonin in mitigating …

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

F Liu, L Zhao, T Wu, W Yu, J Li, W Wang… - Frontiers in …, 2024 - frontiersin.org
As the quality of life improves, the incidence of diabetes mellitus and its microvascular
complications (DMC) continues to increase, posing a threat to people's health and …

Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats Through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway

N Najafi, S Barangi, Z Moosavi… - Biological trace element …, 2024 - Springer
Arsenic (As) exposure is known to cause several neurological disorders through various
molecular mechanisms such as oxidative stress, apoptosis, and autophagy. In the current …

Cardioprotective effect of naringin against the ischemia/reperfusion injury of aged rats

D Shackebaei, M Hesari, S Ramezani-Aliakbari… - Naunyn-Schmiedeberg's …, 2024 - Springer
Aging is known as a main risk factor in the development of cardiovascular diseases.
Naringin (NRG) is a flavonoid compound derived from citrus fruits. It possesses a wide …

Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B/GRP78/PERK signaling pathway

S Zhang, W Tian, X Duan, Q Zhang, L Cao… - Cardiovascular …, 2024 - Springer
Aims Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes,
and the potential strategies for treating DCM are insufficient. Melatonin (Mel) has been …

Melatonin regulates mitochondrial dynamics and mitophagy: Cardiovascular protection

S Rahmani, A Roohbakhsh… - Journal of Cellular …, 2024 - Wiley Online Library
Despite extensive progress in the knowledge and understanding of cardiovascular diseases
and significant advances in pharmacological treatments and procedural interventions …

The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases

Y Wang, Y Li, H Ding, D Li, W Shen… - Journal of cardiovascular …, 2023 - mdpi.com
Sirtuins belong to the class III histone deacetylases and possess nicotinamide adenine
dinucleotide-dependent deacetylase activity. They are involved in the regulation of multiple …

The Cardiovascular Protective Function of Natural Compounds Through AMPK/SIRT1/PGC‐1α Signaling Pathway

S Rahmani, A Roohbakhsh… - Food Science & …, 2024 - Wiley Online Library
Cardiovascular disease (CVD) poses a major risk to human health and exert a heavy
burden on individuals, society, and healthcare systems. Therefore, it is critical to identify …

The potential protective role of carotenoids from saffron: A focus on endoplasmic reticulum stress‐related organ damage

F Mirzavi, A Rajabian, H Hosseini - Food Science & Nutrition, 2024 - Wiley Online Library
The anticancer, antioxidant, and immunomodulatory properties of carotenoids from saffron
or apocarotenoids (eg, crocin, safranal, crocetin, and picrocrocin) have prompted research …