Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters

A Sajid, H Rahman, SV Ambudkar - Nature Reviews Cancer, 2023 - nature.com
Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

Spotlight on photoactivatable liposomes beyond drug delivery: an enabler of multitargeting of molecular pathways

MA Saad, T Hasan - Bioconjugate chemistry, 2022 - ACS Publications
The potential of photoactivating certain molecules, photosensitizers (PS), resulting in
photochemical processes, has long been realized in the form of photodynamic therapy …

Photodynamic Therapy: Critical PDT Theory

D Kessel - Photochemistry and photobiology, 2023 - Wiley Online Library
Photodynamic therapy can be useful for the eradication of malignant cells at sites that are
accessible to light delivery. There are few adverse effects, with many clinical reports …

Engineering photodynamics for treatment, priming and imaging

G Obaid, JP Celli, M Broekgaarden, AL Bulin… - Nature Reviews …, 2024 - nature.com
Photodynamic therapy (PDT) is a photochemistry-based treatment approach that relies on
the activation of photosensitizers by light to locally generate reactive oxygen species that …

Photodynamic priming modulates cellular ATP levels to overcome P‐glycoprotein‐mediated drug efflux in chemoresistant triple‐negative breast cancer

I Rahman, B Liang, A Sajid… - Photochemistry and …, 2024 - Wiley Online Library
Abstract P‐glycoprotein (P‐gp, ABCB1) is a well‐researched ATP‐binding cassette (ABC)
drug efflux transporter linked to the development of cancer multidrug resistance (MDR) …

Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids

A Sorrin, A Dasgupta, K McNaughton… - Cell & Bioscience, 2024 - Springer
Background Within the last decade, poly (ADP-ribose) polymerase inhibitors (PARPi) have
emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data …

Chemophototherapeutic Ablation of Doxorubicin‐Resistant Human Ovarian Tumor Cells

S Ghosh, U Chitgupi, U Sunar… - Photochemistry and …, 2023 - Wiley Online Library
Porphyrin‐phospholipid (PoP) liposomes loaded with Doxorubicin (Dox) have been
demonstrated to be an efficient vehicle for chemophototherapy (CPT). Multidrug resistance …

Phenylspirodrimane with Moderate Reversal Effect of Multidrug Resistance Isolated from the Deep-Sea Fungus Stachybotrys sp. 3A00409

X Ma, M Wu, Z Chen, F Cao, T Zhong, Z Luo, Z Shao… - Molecules, 2024 - mdpi.com
Two new phenylspirodrimanes, stachybotrins K and L (1 and 2), together with eight known
analogues (3–10), were isolated from deep-sea-derived Stachybotrys sp. MCCC 3A00409 …

Investigation of Synergistic Combinatory Treatment of Chemotherapy and Photodynamic Therapy on TNBC Metastatic Potential

J Duong - 2024 - search.proquest.com
Triple-negative breast cancer (TNBC) is a particularly aggressive subtype distinguished by
its varying properties and capacities for growth and metastasis, the leading cause of death in …

Light Activatable Pure Porphyrin Nanoparticles for the Photodynamic Opening of the Blood-Brain Barrier and Glioblastoma Treatment

CT Inglut - 2022 - search.proquest.com
Glioblastoma (GBM) consistently recurs due to infiltrating cancer cells that cannot be
removed by surgery and chemotherapy. The diffusive nature of GBM makes complete …