Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Viruses and intracellular bacterial pathogens (IBPs) have in common the need of suitable
host cells for efficient replication and proliferation during infection. In human infections, the …

Of the many pathogens that infect humans and animals, a large number use cells of the host
organism as protected sites for replication. To reach the relevant intracellular compartments …

Inositol phospholipids have long been known to have an important regulatory role in cell
physiology. The repertoire of cellular processes known to be directly or indirectly controlled …

Successful establishment of infection by bacterial pathogens requires adhesion to host cells,
colonization of tissues, and in certain cases, cellular invasion—followed by intracellular …

Toll-like receptors (TLRs) play a critical role in the immune system as sensors of microbial
infection. Signaling downstream from TLRs is initiated by the recruitment of adaptor proteins …

Eukaryotic cells have systems of internal organelles to synthesize lipids and membrane
proteins, to release secreted proteins, to take up nutrients and to degrade membrane-bound …

An alternative in vitro model of human follicle-associated epithelium (FAE) to study
nanoparticle transport mechanisms by M cells was developed and characterized. The …

With the emergence of multidrug resistant (MDR) bacteria, it is imperative to develop new
intervention strategies. Current antibiotics typically target pathogen rather than host-specific …