Mycobacterium tuberculosis infection of host cells in space and time
C Bussi, MG Gutierrez - FEMS microbiology reviews, 2019 - academic.oup.com
Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
How viral and intracellular bacterial pathogens reprogram the metabolism of host cells to allow their intracellular replication
W Eisenreich, T Rudel, J Heesemann… - Frontiers in cellular and …, 2019 - frontiersin.org
Viruses and intracellular bacterial pathogens (IBPs) have in common the need of suitable
host cells for efficient replication and proliferation during infection. In human infections, the …
host cells for efficient replication and proliferation during infection. In human infections, the …
Endocytosis of viruses and bacteria
P Cossart, A Helenius - Cold Spring Harbor perspectives …, 2014 - cshperspectives.cshlp.org
Of the many pathogens that infect humans and animals, a large number use cells of the host
organism as protected sites for replication. To reach the relevant intracellular compartments …
organism as protected sites for replication. To reach the relevant intracellular compartments …
Phosphoinositides in cell regulation and membrane dynamics
G Di Paolo, P De Camilli - Nature, 2006 - nature.com
Inositol phospholipids have long been known to have an important regulatory role in cell
physiology. The repertoire of cellular processes known to be directly or indirectly controlled …
physiology. The repertoire of cellular processes known to be directly or indirectly controlled …
Bacterial adhesion and entry into host cells
J Pizarro-Cerdá, P Cossart - Cell, 2006 - cell.com
Successful establishment of infection by bacterial pathogens requires adhesion to host cells,
colonization of tissues, and in certain cases, cellular invasion—followed by intracellular …
colonization of tissues, and in certain cases, cellular invasion—followed by intracellular …
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
JC Kagan, R Medzhitov - Cell, 2006 - cell.com
Toll-like receptors (TLRs) play a critical role in the immune system as sensors of microbial
infection. Signaling downstream from TLRs is initiated by the recruitment of adaptor proteins …
infection. Signaling downstream from TLRs is initiated by the recruitment of adaptor proteins …
Organelle identity and the signposts for membrane traffic
Eukaryotic cells have systems of internal organelles to synthesize lipids and membrane
proteins, to release secreted proteins, to take up nutrients and to degrade membrane-bound …
proteins, to release secreted proteins, to take up nutrients and to degrade membrane-bound …
An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells
An alternative in vitro model of human follicle-associated epithelium (FAE) to study
nanoparticle transport mechanisms by M cells was developed and characterized. The …
nanoparticle transport mechanisms by M cells was developed and characterized. The …
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1
C Kuijl, NDL Savage, M Marsman, AW Tuin, L Janssen… - Nature, 2007 - nature.com
With the emergence of multidrug resistant (MDR) bacteria, it is imperative to develop new
intervention strategies. Current antibiotics typically target pathogen rather than host-specific …
intervention strategies. Current antibiotics typically target pathogen rather than host-specific …