The repair of DNA double‑strand breaks (DSBs) is crucial for the preservation of genomic
integrity and the maintenance of cellular homeostasis. Non‑homologous DNA end joining …

The cell nucleus stores the genetic material essential for life, and provides the environment
for transcription, maintenance, and replication of the genome. Moreover, the nucleoplasm is …

The large-scale organization of the genome inside the cell nucleus is critical for the cell's
function. Chromatin—the functional form of DNA in cells—serves as a template for active …

Cell differentiation, the process by which stem cells become specialized cells, is associated
with chromatin reorganization inside the cell nucleus. Here, we measure the chromatin …

In this topical review, we give an overview of the structure and dynamics of a single polymer
chain in active baths, Gaussian or non-Gaussian. The review begins with the discussion of …

The dynamic nature of chromosome organization plays a central role in the regulation of
many crucial processes, such as DNA transcription and replication. However, the molecular …

Abstract 53BP1 is primarily known as a key regulator in DNA double-strand break (DSB)
repair. However, the mechanism of DSB-triggered cohesin modification-modulated …

The last two decades of work on chromosome conformation in eukaryotic nuclei have
revealed a complex and highly regulated hierarchy of architectural features, from self …

The organization and dynamics of human genome govern all cellular processes—directly
impacting the central dogma of biology—yet are poorly understood, especially at large …

Chromosome organization and dynamics are involved in regulating many fundamental
processes such as gene transcription and DNA repair. Experiments unveiled that chromatin …