Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale
BA Rose, T Force, Y Wang - Physiological reviews, 2010 - journals.physiology.org
Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …
Cardiac hypertrophy: the good, the bad, and the ugly
N Frey, EN Olson - Annual review of physiology, 2003 - annualreviews.org
▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …
Electrical and mechanical stimulation of cardiac cells and tissue constructs
The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …
decades, highlighted by the development of human cell derived constructs that have shown …
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
Transplantation of adult bone marrow–derived mesenchymal stem cells has been proposed
as a strategy for cardiac repair following myocardial damage. However, poor cell viability …
as a strategy for cardiac repair following myocardial damage. However, poor cell viability …
Seven-transmembrane-spanning receptors and heart function
Understanding precisely how the heart can recognize and respond to many different
extracellular signalling molecules, such as neurotransmitters, hormones and growth factors …
extracellular signalling molecules, such as neurotransmitters, hormones and growth factors …
Phosphoinositide 3-kinase (p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
JR McMullen, T Shioi, L Zhang… - Proceedings of the …, 2003 - National Acad Sciences
An unresolved question in cardiac biology is whether distinct signaling pathways are
responsible for the development of pathological and physiological cardiac hypertrophy in …
responsible for the development of pathological and physiological cardiac hypertrophy in …
Akt1 is required for physiological cardiac growth
B DeBosch, I Treskov, TS Lupu, C Weinheimer… - Circulation, 2006 - Am Heart Assoc
Background—Postnatal growth of the heart chiefly involves nonproliferative cardiomyocyte
enlargement. Cardiac hypertrophy exists in a “physiological” form that is an adaptive …
enlargement. Cardiac hypertrophy exists in a “physiological” form that is an adaptive …
MEK and the inhibitors: from bench to bedside
A Akinleye, M Furqan, N Mukhi, P Ravella… - Journal of hematology & …, 2013 - Springer
Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been
identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK …
identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK …
Cytoplasmic signaling pathways that regulate cardiac hypertrophy
JD Molkentin, GW Dorn II - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract This review discusses the rapidly progressing field of cardiomyocyte signal
transduction and the regulation of the hypertrophic response. When stimulated by a wide …
transduction and the regulation of the hypertrophic response. When stimulated by a wide …