Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma
Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …
Cancer stem cells: advances in knowledge and implications for cancer therapy
X Chu, W Tian, J Ning, G Xiao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
A Dirkse, A Golebiewska, T Buder, PV Nazarov… - Nature …, 2019 - nature.com
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …
Understanding and targeting cancer stem cells: therapeutic implications and challenges
K Chen, Y Huang, J Chen - Acta Pharmacologica Sinica, 2013 - nature.com
Cancer stem cells (CSCs) have been identified as rare cell populations in many cancers,
including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are …
including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are …
Combination therapy to checkmate Glioblastoma: clinical challenges and advances
Combination therapy is increasingly becoming the cornerstone of current day antitumor
therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival …
therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival …
Emerging treatment strategies for glioblastoma multiforme
SK Carlsson, SP Brothers… - EMBO molecular medicine, 2014 - embopress.org
Glioblastoma multiforme (GBM) is the deadliest form of brain tumor with a more than 90% 5‐
year mortality. GBM has a paltry median survival of 12.6 months attributed to the unique …
year mortality. GBM has a paltry median survival of 12.6 months attributed to the unique …
Genetically edited T-cell membrane coated AIEgen nanoparticles effectively prevents glioblastoma recurrence
W Wang, F Wu, M Mohammadniaei, M Zhang, Y Li… - Biomaterials, 2023 - Elsevier
Glioblastoma stem cells (GSCs) are subpopulations of tumor-initiating cells responsible for
glioblastoma (GBM) tumorigenesis and recurrence. Dual inhibition of vascular endothelium …
glioblastoma (GBM) tumorigenesis and recurrence. Dual inhibition of vascular endothelium …
[HTML][HTML] Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs
AR Safa, MR Saadatzadeh, AA Cohen-Gadol… - Genes & diseases, 2015 - Elsevier
Cancer stem cells (CSCs) or cancer initiating cells (CICs) maintain self-renewal and
multilineage differentiation properties of various tumors, as well as the cellular heterogeneity …
multilineage differentiation properties of various tumors, as well as the cellular heterogeneity …
Rapid 3D bioprinting of glioblastoma model mimicking native biophysical heterogeneity
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor characterized by high
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …
A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma
Owing to the strong absorption of water in the near-infrared (NIR) region near 1.0 μm, this
wavelength is considered unsuitable as an imaging and analytical signal in biological …
wavelength is considered unsuitable as an imaging and analytical signal in biological …