Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma

YA Yabo, SP Niclou, A Golebiewska - Neuro-oncology, 2022 - academic.oup.com
Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …

Cancer stem cells: advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G Xiao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

A Dirkse, A Golebiewska, T Buder, PV Nazarov… - Nature …, 2019 - nature.com
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …

Understanding and targeting cancer stem cells: therapeutic implications and challenges

K Chen, Y Huang, J Chen - Acta Pharmacologica Sinica, 2013 - nature.com
Cancer stem cells (CSCs) have been identified as rare cell populations in many cancers,
including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are …

Combination therapy to checkmate Glioblastoma: clinical challenges and advances

D Ghosh, S Nandi, S Bhattacharjee - Clinical and translational medicine, 2018 - Springer
Combination therapy is increasingly becoming the cornerstone of current day antitumor
therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival …

Emerging treatment strategies for glioblastoma multiforme

SK Carlsson, SP Brothers… - EMBO molecular medicine, 2014 - embopress.org
Glioblastoma multiforme (GBM) is the deadliest form of brain tumor with a more than 90% 5‐
year mortality. GBM has a paltry median survival of 12.6 months attributed to the unique …

Genetically edited T-cell membrane coated AIEgen nanoparticles effectively prevents glioblastoma recurrence

W Wang, F Wu, M Mohammadniaei, M Zhang, Y Li… - Biomaterials, 2023 - Elsevier
Glioblastoma stem cells (GSCs) are subpopulations of tumor-initiating cells responsible for
glioblastoma (GBM) tumorigenesis and recurrence. Dual inhibition of vascular endothelium …

[HTML][HTML] Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs

AR Safa, MR Saadatzadeh, AA Cohen-Gadol… - Genes & diseases, 2015 - Elsevier
Cancer stem cells (CSCs) or cancer initiating cells (CICs) maintain self-renewal and
multilineage differentiation properties of various tumors, as well as the cellular heterogeneity …

Rapid 3D bioprinting of glioblastoma model mimicking native biophysical heterogeneity

M Tang, SK Tiwari, K Agrawal, M Tan, J Dang, T Tam… - Small, 2021 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor characterized by high
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …

A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma

D Kang, HS Kim, S Han, Y Lee, YP Kim, DY Lee… - Nature …, 2023 - nature.com
Owing to the strong absorption of water in the near-infrared (NIR) region near 1.0 μm, this
wavelength is considered unsuitable as an imaging and analytical signal in biological …