The transition from mature oocyte to developing embryo requires a coordinated series of
events, collectively known as egg activation. Egg activation includes changes to egg …

Genetic studies of behavior in the nematode Caenorhabditis elegans have provided an
effective approach to investigate the molecular and cellular basis of nervous system function …

DAF-2, an insulin receptor–like protein, regulates metabolism, development, and aging in
Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that …

To obtain a global view of functional interactions among genes in a metazoan genome, we
computationally integrated interactome data, gene expression data, phenotype data, and …

The organization and coordination of fish schools provide a valuable model to investigate
the genetic architecture of affiliative behaviours and dissect the mechanisms underlying …

The insulin-like signaling pathway maintains a relatively short wild-type lifespan in
Caenorhabditis elegans by phosphorylating and inactivating DAF-16, the ortholog of the …

Phenotypic assays are crucial in genetics; however, traditional methods that rely on human
observation are unsuitable for quantitative, large-scale experiments. Furthermore, there is …

Cilia serve as sensory devices in a diversity of organisms and their defects contribute to
many human diseases. In primary cilia of kidney cells, the transient receptor potential …

Activation of mature oocytes initiates development by releasing the prior arrest of female
meiosis, degrading certain maternal mRNAs while initiating the translation of others, and …

Calcineurin (CaN) is a serine/threonine phosphatase, activated by Ca2+/calmodulin
(Ca2+/CaM). CaN is known to regulate various cellular responses in different organisms. A …