ALS genetics: gains, losses, and implications for future therapies
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …
Protein aggregation in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have …
aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have …
Drosophila as an In Vivo Model for Human Neurodegenerative Disease
With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …
Neuromuscular junction dysfunction in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …
[HTML][HTML] The role of FUS gene variants in neurodegenerative diseases
H Deng, K Gao, J Jankovic - Nature Reviews Neurology, 2014 - nature.com
The neurodegenerative diseases are a diverse group of disorders characterized by
progressive loss of specific groups of neurons. These diseases affect different populations …
progressive loss of specific groups of neurons. These diseases affect different populations …
Nearly 30 years of animal models to study amyotrophic lateral sclerosis: a historical overview and future perspectives
T Bonifacino, RA Zerbo, M Balbi, C Torazza… - International journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …
autonomous neurodegenerative disease characterized by upper and lower motor neuron …
Mechanisms, models and biomarkers in amyotrophic lateral sclerosis
The last 30 years have seen a major advance in the understanding of the clinical and
pathological heterogeneity of amyotrophic lateral sclerosis (ALS), and its overlap with …
pathological heterogeneity of amyotrophic lateral sclerosis (ALS), and its overlap with …
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease
RJ Wheeler, HO Lee, I Poser, A Pal, T Doeleman… - 2019 - europepmc.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with few avenues for
treatment. Many proteins implicated in ALS associate with stress granules, which are …
treatment. Many proteins implicated in ALS associate with stress granules, which are …
Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor Phenotype in …
Dysfunction of two structurally and functionally related proteins, FUS and TAR DNA-binding
protein of 43 kDa (TDP-43), implicated in crucial steps of cellular RNA metabolism can …
protein of 43 kDa (TDP-43), implicated in crucial steps of cellular RNA metabolism can …
Neuromuscular junction dismantling in amyotrophic lateral sclerosis
V Cappello, M Francolini - International journal of molecular sciences, 2017 - mdpi.com
Neuromuscular junction assembly and plasticity during embryonic, postnatal, and adult life
are tightly regulated by the continuous cross-talk among motor nerve endings, muscle fibers …
are tightly regulated by the continuous cross-talk among motor nerve endings, muscle fibers …