Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …

Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …

Gonadal development is a complex process that involves sex determination followed by
divergent maturation into either testes or ovaries. Historically, limited tissue accessibility, a …

Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and are the
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …

With the dramatic development of single-cell RNA sequencing (scRNA-seq) technologies,
the systematic decoding of cell-cell communication has received great research interest. To …

Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …

The testis produces gametes through spermatogenesis and evolves rapidly at both the
morphological and molecular level in mammals,,,,–, probably owing to the evolutionary …

Single-cell multi-omics can provide a unique perspective on tumor cellular heterogeneity.
Most previous single-cell whole-genome RNA sequencing (scWGS-RNA-seq) methods …

Human testis development in prenatal life involves complex changes in germline and
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …

Mammalian male germ cell development is a stepwise cell-fate transition process; however,
the full-term developmental profile of male germ cells remains undefined. Here, by …